Phenotypes associated with this allele

• Allele Symbol: Ufl1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5825300
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ufl1^tm1c(EUCOMM)Wtsi/Ufl1^tm1c(EUCOMM)Wtsi Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N	MGI:5825319

Genotype
MGI:5825319

cn1

• Allelic Composition: Ufl1^{tm1c(EUCOMM)Wtsi}/Ufl1^{tm1c(EUCOMM)Wtsi}; Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:238253 )

• 3 weeks after tamoxifen treatment

hematopoietic system

anemia ( J:238253 )

• in tamoxifen-treated mice

decreased erythroid progenitor cell number ( J:238253 )

• in tamoxifen-treated mice

decreased erythrocyte cell number ( J:238253 )

• in tamoxifen-treated mice

decreased hematocrit ( J:238253 )

• in tamoxifen-treated mice

decreased hemoglobin content ( J:238253 )

• in tamoxifen-treated mice

thrombocytopenia ( J:238253 )

• in tamoxifen-treated mice

decreased leukocyte cell number ( J:238253 )

• in tamoxifen-treated mice

decreased granulocyte number ( J:238253 )

• in tamoxifen-treated mice

decreased lymphocyte cell number ( J:238253 )

• in tamoxifen-treated mice

decreased monocyte cell number ( J:238253 )

• in tamoxifen-treated mice

pancytopenia ( J:238253 )

• in tamoxifen-treated mice

abnormal bone marrow cell physiology ( J:238253 )

• tamoxifen-treated bone marrow cells exhibit increased ER stress and increased unfolded protein response compared with control cells

growth/size/body

weight loss ( J:238253 )

• in tamoxifen-treated mice

cellular

abnormal autophagy ( J:238253 )

• tamoxifen-treated mice exhibit decreased autophagic degradation with increased reactive oxygen species, mitochondrial mass, DNA damage, and enhanced cell death in hematopoietic cells unlike wild-type mice

immune system

decreased leukocyte cell number ( J:238253 )

• in tamoxifen-treated mice

decreased granulocyte number ( J:238253 )

• in tamoxifen-treated mice

decreased lymphocyte cell number ( J:238253 )

• in tamoxifen-treated mice

decreased monocyte cell number ( J:238253 )

• in tamoxifen-treated mice

homeostasis/metabolism

abnormal autophagy ( J:238253 )

• tamoxifen-treated mice exhibit decreased autophagic degradation with increased reactive oxygen species, mitochondrial mass, DNA damage, and enhanced cell death in hematopoietic cells unlike wild-type mice