Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Bhlha15)1Skz
• Allele Name: transgene insertion 1, Stephen F Konieczny
• Allele ID: MGI:5825322
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bhlha15^tm3(cre/ERT2)Skz/Bhlha15^tm3(cre/ERT2)Skz Tg(CAG-Bhlha15)1Skz/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5827856

Genotype
MGI:5827856

cn1

• Allelic Composition: Bhlha15^{tm3(cre/ERT2)Skz}/Bhlha15^{tm3(cre/ERT2)Skz}; Tg(CAG-Bhlha15)1Skz/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:239144 )

N • transgene expression, following exposure to tamoxifen, rescues pancreatic acinar cells from dilation of acini lumens, loss of actin cytoskeleton, loss of connexin32-containing gap junctions, impaired exocytosis, autophagic vacuoles and decreases in acini cell size seen in homozygous Bhlha15^{tm3(cre/ERT2)Skz} mice

N • transgene expression, following exposure to tamoxifen, allows acinar cells to re-establish apical-basal polarity disrupted in homozygous Bhlha15^{tm3(cre/ERT2)Skz} mice; zymogen granules localize to apical pole and increase in size to wild-type diameters