Phenotypes associated with this allele

• Allele Symbol: Btg1^tm1Ftir
• Allele Name: targeted mutation 1, Felice Tirone
• Allele ID: MGI:5825483
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btg1^tm1Ftir/Btg1^tm1Ftir	Not Specified	MGI:5827503

Genotype
MGI:5827503

hm1

• Allelic Composition: Btg1^tm1Ftir/Btg1^tm1Ftir
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:217516 )

• in adult progenitor cells of the dentate gyrus

• in the subventricular zone neural stem cells

decreased neuronal precursor proliferation ( J:217516 )

• impaired neurogenesis and induces exit from the cell cycle in the dentate gyrus

• in the subventricular zone neural stem cells

abnormal dentate gyrus morphology ( J:217516 )

• impaired neurogenesis

behavior/neurological

abnormal contextual conditioning behavior ( J:217516 )

• delayed freezing behavior evoked by two contexts with foot shock delivered in only one context

impaired spatial learning ( J:217516 )

• defective hippocampus-dependent learning in a water maze

cellular

increased neuron apoptosis ( J:217516 )

• in adult progenitor cells of the dentate gyrus

• in the subventricular zone neural stem cells

decreased neuronal precursor proliferation ( J:217516 )

• impaired neurogenesis and induces exit from the cell cycle in the dentate gyrus

• in the subventricular zone neural stem cells