Phenotypes associated with this allele

• Allele Symbol: Pfkfb3^tm1Pec
• Allele Name: targeted mutation 1, Peter Carmeliet
• Allele ID: MGI:5825519
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Pfkfb3^tm1Pec/Pfkfb3^tm1Pec Tg(Cdh5-cre/ERT2)1Rha/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5825525
cn2	Gt(ROSA)26Sor^tm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor^+ Pfkfb3^tm1Pec/Pfkfb3^tm1Pec Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:5825529

Genotype
MGI:5825525

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Pfkfb3^tm1Pec/Pfkfb3^tm1Pec; Tg(Cdh5-cre/ERT2)1Rha/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal retina vasculature morphology ( J:200070 )

• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5

• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature

• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4

• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4

• vessel regression in the retina is increased in tamoxifen treated mice

cellular

decreased endothelial cell proliferation ( J:200070 )

• endothelial cell proliferation is reduced

vision/eye

abnormal retina vasculature morphology ( J:200070 )

• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5

• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature

• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4

• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4

• vessel regression in the retina is increased in tamoxifen treated mice

Genotype
MGI:5825529

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺; Pfkfb3^tm1Pec/Pfkfb3^tm1Pec; Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

cardiovascular system

abnormal retina vasculature morphology ( J:200070 )

• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5

• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature

• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4

• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4

• vessel regression in the retina is increased in tamoxifen treated mice

cellular

decreased endothelial cell proliferation ( J:200070 )

• endothelial cell proliferation is reduced

vision/eye

abnormal retina vasculature morphology ( J:200070 )

• mice treated with tamoxifen at P1-4 show reduced vascular branching in retinal vessels at P5

• mice treated with tamoxifen at P1-4 show fewer distal sprouts with filopodia and fewer number of filopodia in the retinal vasculature

• distal sprouts have fewer side connections in the retinal vasculature of mice treated with tamoxifen at P1-4

• the radial expansion of the vascular plexus is reduced in mice treated with tamoxifen at P1-4

• vessel regression in the retina is increased in tamoxifen treated mice