Phenotypes associated with this allele

• Allele Symbol: Tg(SHBG)4-aGlha
• Allele Name: transgene insertion 4-a, Geoffrey L Hammond
• Allele ID: MGI:5828513
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lepr^db/Lepr^db Tg(SHBG)4-aGlha/0	involves: C57BL/6 * C57BLKS/J * CBA	MGI:5828524
tg2	Tg(SHBG)4-aGlha/0	involves: C57BL/6 * CBA	MGI:5828515

Genotype
MGI:5828524

cx1

• Allelic Composition: Lepr^db/Lepr^db; Tg(SHBG)4-aGlha/0
• Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:232827 )

• progressive increase in body weight from 6 to 12 weeks of age, however a 15-20% reduction in body weight is seen compared to single Lepr^db homozygotes

increased kidney weight ( J:232827 )

increased liver weight ( J:232827 )

• increase in liver weight in both males and females compared to either single heterozygous mice, however liver weight in males is reduced compared to single Lepr^db homozygotes

adipose tissue

abnormal adipose tissue morphology ( J:232827 )

• increase in adipose tissue weight compared to either single heterozygous mice, however visceral adipose tissue weight is reduced compared to single Lepr^db homozygotes

homeostasis/metabolism

abnormal blood homeostasis ( J:232827 )

♂ • plasma levels of SHBG in obese males do not increase from week 4 to week 6 and remain lower at 8 weeks of age unlike in controls and this is due to altered hepatic HNF-4alpha and PPAR-gamma mRNA and protein levels

hyperglycemia ( J:232827 )

• obese mice develop hyperglycemia after 6 weeks of age to a similar extent as single Lepr^db homozygotes

increased circulating testosterone level ( J:232827 )

♂ • total testosterone plasma levels are reduced in obese males

increased circulating insulin level ( J:232827 )

• higher plasma insulin levels in obese males and females comparable to single Lepr^db homozygotes

increased circulating leptin level ( J:232827 )

• higher plasma leptin levels in obese males and females comparable to single Lepr^db homozygotes

increased circulating cholesterol level ( J:232827 )

• obese males and females exhibit higher plasma cholesterol levels comparable to single Lepr^db homozygotes

increased circulating free fatty acids level ( J:232827 )

• higher plasma nonsterified fatty acids level in obese males and females comparable to single Lepr^db homozygotes

increased circulating triglyceride level ( J:232827 )

• obese males and females exhibit higher plasma triglycerides with levels comparable to single Lepr^db homozygotes

increased liver triglyceride level ( J:232827 )

liver/biliary system

increased liver weight ( J:232827 )

• increase in liver weight in both males and females compared to either single heterozygous mice, however liver weight in males is reduced compared to single Lepr^db homozygotes

increased liver triglyceride level ( J:232827 )

hepatic steatosis ( J:232827 )

• mice develop fatty liver

renal/urinary system

increased kidney weight ( J:232827 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:232827

Genotype
MGI:5828515

tg2

• Allelic Composition: Tg(SHBG)4-aGlha/0
• Genetic Background: involves: C57BL/6 * CBA

homeostasis/metabolism

increased circulating testosterone level ( J:239368 )

♂ • increase in serum testosterone levels in 90 day old mutants

reproductive system

reproductive system phenotype ( J:239368 )

N • testis weights, epididymal sperm counts, sperm morphology, male accessory sex organs, and litter sizes are normal and males are fertile up to at least 9 months of age