Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-UBQLN2)356Mont
• Allele Name: transgene insertion 356, Mervyn Monteiro
• Allele ID: MGI:5829042
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Thy1-UBQLN2)356Mont/0	involves: C57BL/6J * SJL	MGI:5896837

Genotype
MGI:5896837

tg1

• Allelic Composition: Tg(Thy1-UBQLN2)356Mont/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:239510 )

N • memory performance is similar to wild-type in novel object recognition test

N • mice do not exhibit evidence of motor difficulties

N • mice do not differ from wild-type in rotarod performance or forelimb/hindlimb grip strength

growth/size/body

growth/size/body region phenotype ( J:239510 )

N • mice do not differ from wild-type in body weight

mortality/aging

mortality/aging ( J:239510 )

N • survival is similar to wild-type

nervous system

nervous system phenotype ( J:239510 )

N • number of inclusions is similar to wild-type

loss of hippocampal neurons ( J:239510 )

• neuronal loss is observed in the dentate gyrus at both 3 and 8 months

• no loss is observed in the CA1 region

astrocytosis ( J:239510 )

• minimal astrocytosis is observed in 8 month old, but not 1, month old mice

decreased motor neuron number ( J:239510 )

• loss of corticospinal neurons at 3 and 8 months of age

• no lower motor neuron loss observed

abnormal axon morphology ( J:239510 )

• increase in number of small-caliber axons as compared to large-caliber axons in gastrocnemius muscle, however, overall number of large-caliber axons is unchanged