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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr39em1Ched
endonuclease-mediated mutation 1, Catherine Hedrick
MGI:5829195
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rr39em1Ched/Rr39em1Ched C57BL/6-Rr39em1Ched MGI:5829816


Genotype
MGI:5829816
hm1
Allelic
Composition		 Rr39em1Ched/Rr39em1Ched
Genetic
Background		 C57BL/6-Rr39em1Ched
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr39em1Ched mutation (1 available); any Rr39 mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased Ly6C low monocyte number ( J:239509 )
• substantial decrease in Ly6low peripheral blood monocytes

immune system
immune system phenotype ( J:239509 )
N
• response to high dose LPS challenge is similar to controls
decreased Ly6C low monocyte number ( J:239509 )
• substantial decrease in Ly6low peripheral blood monocytes

neoplasm
increased tumor growth/size ( J:239509 )
• following injection of B16F10 melanoma cells, mice exhibit a higher tumor burden than wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory