Phenotypes associated with this allele

• Allele Symbol: Il33^{tm2.1(IL33)Arte}
• Allele Name: targeted mutation 2.1, TaconicArtemis
• Allele ID: MGI:5829418
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il33^tm2.1(IL33)Arte/Il33^tm2.1(IL33)Arte	involves: BALB/c * BALB/cJBomTac	MGI:5882550

Genotype
MGI:5882550

hm1

• Allelic Composition: Il33^{tm2.1(IL33)Arte}/Il33^{tm2.1(IL33)Arte}
• Genetic Background: involves: BALB/c * BALB/cJBomTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:227003 )

N • after intranasal challenge with the fungal allergen Alternaria alternata (ALT), the released IL-33 is predominantly found in its reduced (active) form as observed in wild-type controls, reaching a maximum concentration in bronchoalveolar lavage fluid between 5 and 15 min, followed by a rapid decline to undetectable levels by 120 min

N • following ALT challenge, disulphide bonded (inactive) IL-33 levels gradually increase, peaking at 30-120 min and becoming undetectable by 5 h, as in wild-type control mice