All Phenotypes Tert<tm1.1Phan> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tert^tm1.1Phan
targeted mutation 1.1, Sem Phan
MGI:5829569

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tert^tm1.1Phan/Tert^tm1.1Phan Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0	involves: C57BL/6 * DBA/2	MGI:5829793

Allelic Composition	Tert^tm1.1Phan/Tert^tm1.1Phan Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tert^tm1.1Phan mutation (1 available); any Tert mutation (55 available)
Tg(Col1a2-cre/ERT,-ALPP)7Cpd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased apoptosis ( J:239734 )

• tamoxifen treated lung fibroblasts treated with an apoptotic stimulus exhibit a 4 fold increase in apoptosis as compared to controls

decreased lung fibroblast proliferation ( J:239734 )

• stimulated tamoxifen treated lung fibroblasts fail to proliferate as compared to controls

respiratory system

pulmonary fibrosis ( J:239734 )

• administration of bleomycin (to induce pulmonary fibrosis) to tamoxifen treated mice results in less extensive fibrosis and more diffuse fibrotic lesions affecting larger areas of lungs as compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24