growth/size/body
• mice are smaller than controls
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hearing/vestibular/ear
• loss of inner hair cells throughout cochlea
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• loss of outer hair cells throughout cochlea
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• basal turn of organ of Corti lacks the tunnel of Corti and any distinguishable hair cells; the apex and middle turns are near-normal
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• elevated hearing threshold at 32 kHz beginning at 2 months
• hearing loss progresses at all frequencies (12 and 24 kHz) with age
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nervous system
• loss of inner hair cells throughout cochlea
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• loss of outer hair cells throughout cochlea
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• decreased density of spiral ganglion cells in the basal turn of organ of Corti
• spiral ganglion cells in the basal turn of organ of Corti appear abnormal
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