All Phenotypes Gt(ROSA)26Sor<tm1(SPOP*F133V)Mrbn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}
targeted mutation 1, Mark A Rubin
MGI:5882069

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten⁺ Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:6275174
cn2	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Pbsn-cre)4Prb/0	involves: 129S1/Sv * C57BL/6 * DBA/2	MGI:6275175
cn3	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)4Prb/0	involves: C57BL/6 * DBA/2	MGI:6275172

Allelic Composition	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (86 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:239660 )

• 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

• mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

neoplasm

increased prostate gland adenocarcinoma incidence ( J:239660 )

• 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

• mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

reproductive system

increased prostate gland adenocarcinoma incidence ( J:239660 )

• 1 of 5 mice older than 12 months exhibit areas of invasive prostate carcinoma

increased prostate intraepithelial neoplasia incidence ( J:239660 )

• mice exhibit a high penetrance of focal areas of high-grade prostatic intraepithelial neoplasia by 6 months of age, characterized by nuclear atypia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:239660

Allelic Composition	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Pten^tm2.1Ppp/Pten^tm2.1Ppp Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

neoplasm

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

reproductive system

increased prostate gland adenocarcinoma incidence ( J:239660 )

• mice exhibit severely enlarged prostates with areas of solid tumor by 12 months of age

• 80% of mice display invasive, poorly differentiated carcinomas; tumors are highly proliferative with transitional sarcomatoid differentiation and maintain expression of androgen receptor

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:239660

Allelic Composition	Gt(ROSA)26Sor^{tm1(SPOP*F133V)Mrbn}/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:239660 )

• rare areas in prostate show outlier levels of androgen receptor expression and rare cells show cytologic atypia with enlarged nuclei in mice older than 12 months

• however, mice show minimal alterations in prostate grandular architecture and histology, no differences in proliferation or androgen receptor expression

reproductive system

abnormal prostate gland morphology ( J:239660 )

• rare areas in prostate show outlier levels of androgen receptor expression and rare cells show cytologic atypia with enlarged nuclei in mice older than 12 months

• however, mice show minimal alterations in prostate grandular architecture and histology, no differences in proliferation or androgen receptor expression

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