Phenotypes associated with this allele

• Allele Symbol: Ube3a^tm1.1Bdph
• Allele Name: targeted mutation 1.1, Benjamin D Philpot
• Allele ID: MGI:5882092
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ube3a^tm1.1Bdph/Ube3a^+ 7630403G23Rik^Tg(Th-cre)1Tmd/7630403G23Rik^+	B6.Cg-Ube3a^tm1.1Bdph 7630403G23Rik^Tg(Th-cre)1Tmd	MGI:5882094

Genotype
MGI:5882094

cn1

• Allelic Composition: Ube3a^tm1.1Bdph/Ube3a⁺; 7630403G23Rik^{Tg(Th-cre)1Tmd}/7630403G23Rik⁺
• Genetic Background: B6.Cg-Ube3a^tm1.1Bdph 7630403G23Rik^{Tg(Th-cre)1Tmd}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal operant conditioning behavior ( J:235694 )

• when the allele is inherited maternally, mice nose poke more for 30 Hz stimulation than controls, indicating enhanced motivation

nervous system

abnormal GABA-mediated receptor currents ( J:235694 )

• mice with a maternally inherited allele show a greater than 50% reduction in peak amplitude of GABAergic currents relative to controls, while current decay kinetics are normal, indicating decreased GABA co-release

• mice with a maternally inherited allele exhibit diminished GABAergic currents at 30 Hz stimulation of ventral tegmental area-to-nucleus accumbens (VTA-to-NAc) terminals compared to controls

• expression of exogenous vesicular GABA transporter (VGAT) within TH+ terminals normalizes optical intracranial self-stimulation in mice with a maternally inherited allele

• however, no changes in optically evoked dopamine release in TH+ VTA-to-NAc terminals is seen in mice with a maternally inherited allele and mice also exhibit normal glutamatergic co-release with optical stimulation of VTA-to-NAc termimals