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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aggf1tm1Qkw
targeted mutation 1, Qing Kenneth Wang
MGI:5882327
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aggf1tm1Qkw/Aggf1tm1Qkw involves: 129 * C57BL/6 MGI:5882329
ht2
 		Aggf1tm1Qkw/Aggf1+ involves: 129 * C57BL/6 MGI:5882328


Genotype
MGI:5882329
hm1
Allelic
Composition		 Aggf1tm1Qkw/Aggf1tm1Qkw
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aggf1tm1Qkw mutation (0 available); any Aggf1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality prior to organogenesis ( J:239252 )
• embryos die before E8.5




Genotype
MGI:5882328
ht2
Allelic
Composition		 Aggf1tm1Qkw/Aggf1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aggf1tm1Qkw mutation (0 available); any Aggf1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal vitelline vasculature morphology ( J:239252 )
• defective vascular development in yolk sacs

mortality/aging
embryonic lethality, incomplete penetrance ( J:239252 )
• fewer than the expected numbers of mice are recovered

cardiovascular system
abnormal vascular development ( J:239252 )
• defective vascular development in embryos and yolk sacs
abnormal tumor vascularization ( J:239252 )
• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
abnormal vitelline vasculature morphology ( J:239252 )
• defective vascular development in yolk sacs
internal hemorrhage ( J:239252 )
• about 35% of adult mice show hemorrhages in the brain, lungs, and other tissues
abnormal vascular endothelial cell physiology ( J:239252 )
• microvascular endothelial cells (MECs) show decreased capability to form capillary tubes
increased vascular permeability ( J:239252 )
• adult mice show increased vascular permeability

neoplasm
abnormal tumor vascularization ( J:239252 )
• implanted melanoma cells that develop into tumors show decreased vascular density compared to controls
decreased tumor incidence ( J:239252 )
• tumor growth of both B16F10 and B16F0 melanoma cells is inhibited compared to growth in wild-type mice

respiratory system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory