Phenotypes associated with this allele

• Allele Symbol: Ppargc1a^tm1Aztc
• Allele Name: targeted mutation 1, AstraZenica Transgenic Center
• Allele ID: MGI:5882330
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppargc1a^tm1Aztc/Ppargc1a^tm1Aztc	C57BL/6-Ppargc1a^tm1Aztc	MGI:5882338
ht2	Ppargc1a^tm1Aztc/Ppargc1a^+	C57BL/6-Ppargc1a^tm1Aztc	MGI:5882334

Genotype
MGI:5882338

hm1

• Allelic Composition: Ppargc1a^tm1Aztc/Ppargc1a^tm1Aztc
• Genetic Background: C57BL/6-Ppargc1a^tm1Aztc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased body fat mass ( J:82809 )

♀

growth/size/body

decreased body fat mass ( J:82809 )

♀

decreased lean body mass ( J:82809 )

♀

decreased body weight ( J:82809 )

♀

homeostasis/metabolism

decreased circulating glucose level ( J:82809 )

♀

decreased circulating insulin level ( J:82809 )

♀

Genotype
MGI:5882334

ht2

• Allelic Composition: Ppargc1a^tm1Aztc/Ppargc1a⁺
• Genetic Background: C57BL/6-Ppargc1a^tm1Aztc

adipose tissue

decreased retroperitoneal fat pad weight ( J:82809 )

• significantly decreased

growth/size/body

decreased lean body mass ( J:82809 )

♂ • significantly decreased

decreased body weight ( J:82809 )

♂ • significantly decreased

decreased body length ( J:82809 )

♂ • significantly decreased

increased kidney weight ( J:82809 )

• significantly increased

skeleton

decreased bone mineral content ( J:82809 )

♂ • significantly decreased

behavior/neurological

decreased food intake ( J:82809 )

endocrine/exocrine glands

increased adrenal gland weight ( J:82809 )

• significantly increased

increased thymus weight ( J:82809 )

• significantly increased

hematopoietic system

increased thymus weight ( J:82809 )

• significantly increased

thrombocytopenia ( J:82809 )

• heterozygous mutant mice exhibit lower platelet counts than their wild-type littermates

homeostasis/metabolism

decreased circulating cholesterol level ( J:82809 )

• heterozygous mutant mice exhibit lower total plasma cholesterol than their wild-type littermates

increased circulating alkaline phosphatase level ( J:82809 )

decreased respiratory quotient ( J:82809 )

• heterozygous mutant mice have a lower respiratory exchange ratio (RER) than their wild-type littermates

immune system

increased thymus weight ( J:82809 )

• significantly increased

renal/urinary system

increased kidney weight ( J:82809 )

• significantly increased