Phenotypes associated with this allele

• Allele Symbol: Plaat3^tm1.1Hsul
• Allele Name: targeted mutation 1.1, Hei Sul
• Allele ID: MGI:5882500
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plaat3^tm1.1Hsul/Plaat3^tm1.1Hsul	B6.129P2-Pla2g16^tm1.1Hsul	MGI:5882532

Genotype
MGI:5882532

hm1

• Allelic Composition: Plaat3^tm1.1Hsul/Plaat3^tm1.1Hsul
• Genetic Background: B6.129P2-Pla2g16^tm1.1Hsul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased fatty acid oxidation ( J:239202 )

decreased susceptibility to diet-induced obesity ( J:239202 )

• beginning at age 11 weeks and worsening with age, mice fed a high-fat diet exhibit reduced weight gain compared to wild-type mice

decreased circulating leptin level ( J:239202 )

• whether mice are fed standard chow or a high-fat diet

decreased circulating free fatty acids level ( J:239202 )

• whether mice are fed standard chow or a high-fat diet with higher liver fatty acid uptake

increased circulating alanine transaminase level ( J:239202 )

decreased phospholipase A2 level ( J:239202 )

• in adipose tissue

increased oxygen consumption ( J:239202 )

abnormal glucose homeostasis ( J:239202 )

• decreased glycolysis

increased circulating glucose level ( J:239202 )

• in mice fed a high-fat, but not a standard, diet

increased fasting circulating glucose level ( J:239202 )

• when fed a high-fat diet but not standard diet

increased circulating insulin level ( J:239202 )

• whether mice are fed standard chow or a high-fat diet

abnormal glycogen homeostasis ( J:239202 )

• decreased glycogen synthesis

insulin resistance ( J:239202 )

• whether mice are fed standard chow or a high-fat diet

• hepatic insulin resistance

decreased circulating adiponectin level ( J:239202 )

• whether mice are fed standard chow or a high-fat diet

decreased triglyceride level ( J:239202 )

• in the liver and adipose tissue with an increase in triacylglycerol turnover

decreased circulating triglyceride level ( J:239202 )

decreased liver triglyceride level ( J:239202 )

• in mice fed a high-fat, but not a standard, diet

abnormal lipid metabolism ( J:239202 )

• increase in triacylglycerol turnover due to altered triacylglycerol hydrolysis in white adipose tissue

enhanced lipolysis ( J:239202 )

• increase in triacylglycerol turnover due to altered triacylglycerol hydrolysis in white adipose tissue

• increased isoproterenol-induced lipolysis in adipose tissue

adipose tissue

adipose tissue phenotype ( J:239202 )

N • mice exhibit normal adipogenesis

decreased white fat cell size ( J:239202 )

• greater frequency of small adipocytes with a reduction in midsized and large adipocytes

decreased epididymal fat pad weight ( J:239202 )

• mice fed standard chow exhibit reduced weight gain compared with wild-type mice

decreased inguinal fat pad weight ( J:239202 )

• mice fed standard chow exhibit reduced weight gain compared with wild-type mice

decreased renal fat pad weight ( J:239202 )

• mice fed standard chow exhibit reduced weight gain compared with wild-type mice

liver/biliary system

enlarged liver ( J:239202 )

• in mice fed a high-fat diet

decreased liver triglyceride level ( J:239202 )

• in mice fed a high-fat, but not a standard, diet

hepatic steatosis ( J:239202 )

pale liver ( J:239202 )

• with numerous, lipid-laden vacuoles in hepatocytes

growth/size/body

increased lean body mass ( J:239202 )

decreased susceptibility to weight gain ( J:239202 )

• mice fed standard chow exhibit reduced weight gain compared with wild-type mice

decreased susceptibility to diet-induced obesity ( J:239202 )

• beginning at age 11 weeks and worsening with age, mice fed a high-fat diet exhibit reduced weight gain compared to wild-type mice

enlarged liver ( J:239202 )

• in mice fed a high-fat diet

cellular

decreased cellular glucose uptake ( J:239202 )

• decreased whole-body glucose uptake

increased fatty acid oxidation ( J:239202 )