Analysis Tools|
Allele Symbol Allele Name Allele ID |
Map3k3tm1.1Mlkn targeted mutation 1.1, Mark Kahn MGI:5882560 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen injected mice show full rescue of cerebral cavernous malformation lesion formation
(J:232707)
• tamoxifen injected mice do not exhibit cerebral cavernous malformation lesions
(J:250906)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• area occupied by cardiac jelly in the trabeculae is decreased only 25% at E10.5, indicating some rescue of cardiac jelly
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryonic lethality prior to E12.5
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• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal
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• thin myocardial cell layer
• however, cardiac jelly is preserved and endocardial-myocardial separation at E10.5 is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen injected mice show a reduction in the number and size of vascular lesions in the brain at P11, with nearly complete prevention of lesions
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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