Phenotypes associated with this allele

• Allele Symbol: Foxc2^tm1.1Miu
• Allele Name: targeted mutation 1.1, Naoyuki Miura
• Allele ID: MGI:5882729
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Foxc2^tm1.1Miu/Foxc2^tm1.1Miu Nkx2-5^tm1(cre)Rjs/Nkx2-5^+	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL	MGI:6879488
cn2	Foxc2^tm1.1Miu/Foxc2^tm1.1Miu Tg(Tek-cre)1Ywa/0	involves: C57BL/6 * C57BL/6J * SJL	MGI:6879489

Genotype
MGI:6879488

cn1

• Allelic Composition: Foxc2^tm1.1Miu/Foxc2^tm1.1Miu; Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:316530 )

• all mice die soon after birth

cardiovascular system

interrupted aortic arch, type b ( J:316530 )

• at E18.5, seven of 12 embryos show an interrupted aortic arch type B (IAA-B), where part of the aortic arch between the left common carotid artery and the left subclavian artery is absent

• defect in aortic arch remodeling is clearly visible (as IAA-B) at E13.5, but not at E12.5, indicating that initial formation and patterning of pharyngeal arch arteries is normal

• however, embryos appear grossly normal and show spontaneous movements and cardiac pulsations at E14.5

perimembraneous ventricular septal defect ( J:316530 )

• at E18.5, five of 12 embryos show a VSD where membranous portions of the ventricular septum fail to fuse

craniofacial

craniofacial phenotype ( J:316530 )

N • newborn pups exhibit no apparent craniofacial defects

skeleton

skeleton phenotype ( J:316530 )

N • newborn pups exhibit no apparent skeletal defects

Genotype
MGI:6879489

cn2

• Allelic Composition: Foxc2^tm1.1Miu/Foxc2^tm1.1Miu; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

mortality/aging

neonatal lethality, complete penetrance ( J:316530 )

• all mice die soon after birth; lethality is likely secondary to heart failure

cardiovascular system

cardiovascular system phenotype ( J:316530 )

N • embryos exhibit no detectable aortic arch or ventricular septum defects at E18.5; no aortic arch remodeling defect is seen at E13.5

pericardial effusion ( J:316530 )

• at E14.5

homeostasis/metabolism

pericardial effusion ( J:316530 )

• at E14.5

lymphedema ( J:316530 )

• at E14.5, embryos exhibit severe peripheral edema with fluid accumulation in the lymphatic system

immune system

abnormal lymphatic vessel morphology ( J:316530 )

• presence of peripheral edema at E14.5 suggests altered embryonic lymphatic vessel development

craniofacial

craniofacial phenotype ( J:316530 )

N • newborn pups exhibit no apparent craniofacial defects

skeleton

skeleton phenotype ( J:316530 )

N • newborn pups exhibit no apparent skeletal defects