Phenotypes associated with this allele

• Allele Symbol: Agtr1a^tm3Tma
• Allele Name: targeted mutation 3, Taiji Matsusaka
• Allele ID: MGI:5883021
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Agtr1a^tm3Tma/Agtr1a^tm3Tma Tg(Nphs1-cre)10Mska/0 Tg(Nphs1-IL2RA)18Mska/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2	MGI:5902399
cn2	Agtr1a^tm3Tma/Agtr1a^tm3Tma Tg(Nphs1-cre)10Mska/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:5902398

Genotype
MGI:5902399

cn1

• Allelic Composition: Agtr1a^tm3Tma/Agtr1a^tm3Tma; Tg(Nphs1-cre)10Mska/0; Tg(Nphs1-IL2RA)18Mska/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:240316 )

N • mice do not show proteinuria and renal morphology is normal

N • mice injected with an immunotoxin, anti-Tac(Fv)-PE38 (LMB2) develop the same level of glomerulosclerosis as controls

N • mice injected with LMB2 to induce glomerular injury that are treated with angiotensin II type 1 receptor blocker (ARB) show attenuation of glomerulosclerosis progression

Genotype
MGI:5902398

cn2

• Allelic Composition: Agtr1a^tm3Tma/Agtr1a^tm3Tma; Tg(Nphs1-cre)10Mska/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

cardiovascular system

cardiovascular system phenotype ( J:240316 )

N • mice exhibit normal blood pressure at 4 months

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:240316 )

N • mice exhibit a normal urinary albumin:creatinine ratio at 4 months

N • mice infused with angiotensin II develop a similar degree of microalbuminuria as controls

renal/urinary system

renal/urinary system phenotype ( J:240316 )

N • renal histology is normal from 1 to 12 months of age