Analysis Tools
mortality/aging
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• mice exhibit an increased risk of death as mice age
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growth/size/body
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• mice show decreased weight with age
• mice begin declining on average at 76 +/- 51 days
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• a small percentage of mice develop hepatomegaly
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• spleen is enlarged in end-stage mice
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hematopoietic system
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• spleen is enlarged in end-stage mice
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• modest microcytic anemia
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• modest but significant reduction in red blood cells
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• modest but significant reduction in hematocrit
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• total white blood cell counts are modestly but significantly elevated
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• increase in the number of circulating neutrophils
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• lymphocytic stromal cell hyperplasia
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homeostasis/metabolism
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• 18 of 36 cytokines and chemokines are elevated in the plasma, including IL-22, IL-28, IL-23, IL-6, MCP-1, IL-31, IL-5, IL-10, IL-1beta, IL-15/IL-15R, IFN-gamma, IL-3, GM-CSF, IL-17A, IFN-alpha, MIP-1B, LIF, and growth-related oncogene alpha
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immune system
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• spleen is enlarged in end-stage mice
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• total white blood cell counts are modestly but significantly elevated
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• increase in the number of circulating neutrophils
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• lymphocytic stromal cell hyperplasia
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• 18 of 36 cytokines and chemokines are elevated in the plasma, including IL-22, IL-28, IL-23, IL-6, MCP-1, IL-31, IL-5, IL-10, IL-1beta, IL-15/IL-15R, IFN-gamma, IL-3, GM-CSF, IL-17A, IFN-alpha, MIP-1B, LIF, and growth-related oncogene alpha
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• a subset of end-stage mice develop enlarged cervical lymph nodes
• both B and T cells are greatly expanded within the lymph nodes
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• mice develop classic features of autoimmunity including anti-dsDNA antibodies and increased cytokine and chemokine levels
• wild-type recipients transplanted with homozygous mutant bone marrow are smaller, have larger spleens, some have enlarged cervical lymph nodes, lower platelet count, reduced hematocrit, elevated cytokines, and elevated anti-dsDNA antibody activity indicating autoimmunity development
• homozygous mutant recipients transplanted with wild-type bone marrow show increased weight, increased life span, decreased level of splenomegaly, fewer neutrophils, elevated platelet counts, reduced cytokine levels and reduced anti-dsDNA activity
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• mice exhibit an accumulation of anti-dsDNA antibody which is sustained in plasma in mice greater than 300 days of age
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dermatitis
(
J:240357
)
integument
dermatitis
(
J:240357
)
liver/biliary system
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• a small percentage of mice develop hepatomegaly
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cardiovascular system
respiratory system
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autoimmune disease | DOID:417 |
OMIM:109100 |
J:240357 | |
