Analysis Tools
mortality/aging
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• mice exhibit increased mortality at later ages
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growth/size/body
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• mice show decreased weight with age
• mice begin declining on average at 37 +/- 29 days
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• a small percentage of mice develop hepatomegaly
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• spleens are enlarged at P50 but not at P25
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hematopoietic system
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• modest microcytic anemia
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• modest but significant reduction in red blood cells
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• modest but significant reduction in hematocrit
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• platelet count is already reduced by P50 and is persistently depressed in older mice
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• total white blood cell counts are modestly but significantly elevated
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• mice begin to exhibit a persistent and significant increase in neutrophil numbers at 100 days of age
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• lymphocytic stromal cell hyperplasia
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• CD25+CD4+ T cells are elevated in spleens of P400 mice
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• spleens display a disruption of red and white pulp boundaries
• analysis of V(D)J recombination in spleens shows polyclonal populations of B and T cells
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• spleens are enlarged at P50 but not at P25
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• mice show an increase in splenocytes derived from several lineages, including CD19+B220+ cells, CD3+CD4+ T cells, and CD11b+Ly6G+ neutrophils
• however, no histological changes in cellularity of the bone marrow is seen
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• IgG autoantibodies targeting 113 of 124 antigens are elevated
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• IgM autoantibodies targeting 117 of 124 antigens are elevated
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homeostasis/metabolism
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• at 50 days of age, IL-31, IL15/IL-15R, and GM-CSF are elevated in plasma
• 18 of 36 cytokines and chemokines are elevated in the plasma at P100-300, including IL-22, IL-28, IL-23, IL-6, MCP-1, IL-31, IL-5, IL-10, IL-1beta, IL-15/IL-15R, IFN-gamma, IL-3, GM-CSF, IL-17A, IFN-alpha, MIP-1B, LIF, and growth-related oncogene alpha
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immune system
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• total white blood cell counts are modestly but significantly elevated
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• mice begin to exhibit a persistent and significant increase in neutrophil numbers at 100 days of age
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• lymphocytic stromal cell hyperplasia
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• CD25+CD4+ T cells are elevated in spleens of P400 mice
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• spleens display a disruption of red and white pulp boundaries
• analysis of V(D)J recombination in spleens shows polyclonal populations of B and T cells
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• spleens are enlarged at P50 but not at P25
|
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• mice show an increase in splenocytes derived from several lineages, including CD19+B220+ cells, CD3+CD4+ T cells, and CD11b+Ly6G+ neutrophils
• however, no histological changes in cellularity of the bone marrow is seen
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• IgG autoantibodies targeting 113 of 124 antigens are elevated
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• IgM autoantibodies targeting 117 of 124 antigens are elevated
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• at 50 days of age, IL-31, IL15/IL-15R, and GM-CSF are elevated in plasma
• 18 of 36 cytokines and chemokines are elevated in the plasma at P100-300, including IL-22, IL-28, IL-23, IL-6, MCP-1, IL-31, IL-5, IL-10, IL-1beta, IL-15/IL-15R, IFN-gamma, IL-3, GM-CSF, IL-17A, IFN-alpha, MIP-1B, LIF, and growth-related oncogene alpha
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• mice develop classic features of autoimmunity
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• IgM autoantibodies targeting 117 of 124 antigens and IgG autoantibodies targeting 113 of 124 antigens are elevated
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• mice exhibit accumulation of anti-dsDNA antibody between P50 and P100
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• mice show increased neural inflammation in the cortex
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• immune cell infiltrates in the liver
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dermatitis
(
J:240357
)
integument
dermatitis
(
J:240357
)
liver/biliary system
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• a small percentage of mice develop hepatomegaly
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• immune cell infiltrates in the liver
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nervous system
| N |
• number of spinal motor neurons is normal and no gross abnormalities of the motor cortex or other regions of the brain are seen
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• mice show increased neural inflammation in the cortex
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respiratory system
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autoimmune disease | DOID:417 |
OMIM:109100 |
J:240357 | |
