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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Podxl2tm1c(EUCOMM)Wtsi
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:5883834
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL MGI:6711207
cn2
 		Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:6711208


Genotype
MGI:6711207
cn1
Allelic
Composition		 Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Cell Lines EPD0647_7_C06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl2tm1c(EUCOMM)Wtsi mutation (0 available); any Podxl2 mutation (26 available)
Podxltm1Parl mutation (0 available); any Podxl mutation (17 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:240523 )
N
• mice show no delay in timely lumen formation in developing epithelial tubules in the kidney at E14.5




Genotype
MGI:6711208
cn2
Allelic
Composition		 Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl2tm1c(EUCOMM)Wtsi mutation (0 available); any Podxl2 mutation (26 available)
Podxltm1Parl mutation (0 available); any Podxl mutation (17 available)
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:240523 )
• mice die in the neonatal period

renal/urinary system
renal/urinary system phenotype ( J:240523 )
N
• mice show no obvious defects in nephron lumen formation or luminal continuity indicating normal early stages of nephrogenesis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory