Phenotypes associated with this allele

• Allele Symbol: Fgfbp1^tm1Gvdz
• Allele Name: targeted mutation 1, Gregorio Valdez
• Allele ID: MGI:5888855
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz	involves: 129S5/SvEvBrd	MGI:5902839
cx2	Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz Tg(Thy1-YFP)16Jrs/0	involves: 129S5/SvEvBrd * C57BL/6J * CBA	MGI:5902844
cx3	Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz Tg(SOD1*G93A)1Gur/0 Tg(Thy1-YFP)16Jrs/0	involves: 129S5/SvEvBrd * C57BL/6J * CBA * SJL	MGI:5902841

Genotype
MGI:5902839

hm1

• Allelic Composition: Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuromuscular synapse morphology ( J:237911 )

• less apposed presynaptic and postsynaptic sites at P8 with more multiple innervation

• however, neuromuscular junctions are normal at P16

Genotype
MGI:5902844

cx2

• Allelic Composition: Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz; Tg(Thy1-YFP)16Jrs/0
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

nervous system

abnormal neuromuscular synapse morphology ( J:237911 )

• increased number of fragmented neuromuscular junctions at 12 months compared with control mice

Genotype
MGI:5902841

cx3

• Allelic Composition: Fgfbp1^tm1Gvdz/Fgfbp1^tm1Gvdz; Tg(SOD1*G93A)1Gur/0; Tg(Thy1-YFP)16Jrs/0
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA * SJL

mortality/aging

premature death ( J:237911 )

• accelerated in female and male mice compared with Tg(SOD1*G93A)1Gur mice

nervous system

abnormal neuromuscular synapse morphology ( J:237911 )

• fewer fully innervated neuromuscular junctions (NMJs) than in Tg(SOD1*G93A)1Gur mice with more partially and completely denervated NMJs