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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfbp1tm1Gvdz
targeted mutation 1, Gregorio Valdez
MGI:5888855
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz involves: 129S5/SvEvBrd MGI:5902839
cx2
 		Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz
Tg(Thy1-YFP)16Jrs/0 		involves: 129S5/SvEvBrd * C57BL/6J * CBA MGI:5902844
cx3
 		Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz
Tg(SOD1*G93A)1Gur/0
Tg(Thy1-YFP)16Jrs/0 		involves: 129S5/SvEvBrd * C57BL/6J * CBA * SJL MGI:5902841


Genotype
MGI:5902839
hm1
Allelic
Composition		 Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfbp1tm1Gvdz mutation (0 available); any Fgfbp1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:237911 )
• less apposed presynaptic and postsynaptic sites at P8 with more multiple innervation
• however, neuromuscular junctions are normal at P16




Genotype
MGI:5902844
cx2
Allelic
Composition		 Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz
Tg(Thy1-YFP)16Jrs/0
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfbp1tm1Gvdz mutation (0 available); any Fgfbp1 mutation (19 available)
Tg(Thy1-YFP)16Jrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuromuscular synapse morphology ( J:237911 )
• increased number of fragmented neuromuscular junctions at 12 months compared with control mice




Genotype
MGI:5902841
cx3
Allelic
Composition		 Fgfbp1tm1Gvdz/Fgfbp1tm1Gvdz
Tg(SOD1*G93A)1Gur/0
Tg(Thy1-YFP)16Jrs/0
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfbp1tm1Gvdz mutation (0 available); any Fgfbp1 mutation (19 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
Tg(Thy1-YFP)16Jrs mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:237911 )
• accelerated in female and male mice compared with Tg(SOD1*G93A)1Gur mice

nervous system
abnormal neuromuscular synapse morphology ( J:237911 )
• fewer fully innervated neuromuscular junctions (NMJs) than in Tg(SOD1*G93A)1Gur mice with more partially and completely denervated NMJs




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory