Phenotypes associated with this allele

• Allele Symbol: Anxa10^em1Siag
• Allele Name: endonuclease-mediated mutation 1, Shinji Sasaki
• Allele ID: MGI:5888868
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Anxa10^em1Siag/Anxa10^em1Siag	involves: C57BL/6 * DBA	MGI:5896434
ht2	Anxa10^em1Siag/Anxa10^+	involves: C57BL/6 * DBA	MGI:5896436

Genotype
MGI:5896434

hm1

• Allelic Composition: Anxa10^em1Siag/Anxa10^em1Siag
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

maternal effect ( J:239403 )

♀ • litter sizes from crosses of homozygous females are reduced by ~30% relative to those of wild-type females, indicating partial embryonic lethality

♀ • some embryos of homozygous females die between E4.5 and E12.5

♀ • however, surviving embryos exhibit healthy placentas at E15.5 and ~70% pups are born normally

reproductive system

reproductive system phenotype ( J:239403 )

♀N • female homozygotes exhibit normal oocytes and corpora lutea at E15.5, indicating normal follicular development and ovulation

embryo

embryo phenotype ( J:239403 )

♀N • placentas of female homozygotes lack platelet thrombi and do not exhibit anemia, as both fetal erythrocytes with nuclei and maternal erythrocytes are present in the labyrinth zone at E15.5

Genotype
MGI:5896436

ht2

• Allelic Composition: Anxa10^em1Siag/Anxa10⁺
• Genetic Background: involves: C57BL/6 * DBA

cellular

maternal effect ( J:239403 )

♀ • litter sizes from crosses of heterozygous females are reduced by ~30% relative to those of wild-type females, indicating partial embryonic lethality

♀ • litter sizes of homozygous and heterozygous females are not statistically different