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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc39a7tm1.1Tfk
targeted mutation 1, Toshiyuki Fukada
MGI:5888872
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5902448
cn2
 		Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:5902447


Genotype
MGI:5902448
cn1
Allelic
Composition		 Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
Slc39a7tm1.1Tfk mutation (0 available); any Slc39a7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased mortality induced by gamma-irradiation ( J:236234 )
• all tamoxifen-treated mice die within 4 days of gamma irradiation

digestive/alimentary system
digestive/alimentary phenotype ( J:236234 )
N
• tamoxifen-treated mice exhibit normal epithelial organoid and crypt-derived epithelial organoid formation
abnormal intestine development ( J:236234 )
• tamoxifen-treated mice exhibit massive apoptosis of transit-amplifying cells due to increased ER stress
decreased Paneth cell number ( J:236234 )
• degeneration of Paneth cells in tamoxifen-treated mice

homeostasis/metabolism
increased mortality induced by gamma-irradiation ( J:236234 )
• all tamoxifen-treated mice die within 4 days of gamma irradiation

endocrine/exocrine glands
decreased Paneth cell number ( J:236234 )
• degeneration of Paneth cells in tamoxifen-treated mice




Genotype
MGI:5902447
cn2
Allelic
Composition		 Slc39a7tm1.1Tfk/Slc39a7tm1.1Tfk
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a7tm1.1Tfk mutation (0 available); any Slc39a7 mutation (29 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:236234 )
• mice treated with tamoxifen for 5 days exhibit complete lethality by 7 days
• mice treated with tamoxifen for 3 days exhibit some lethality by day 4
• however, most mice survive at day 4 when treated with tamoxifen for 3 days

digestive/alimentary system
abnormal enterocyte physiology ( J:236234 )
• loss of epithelial integrity and stem cells in intestinal epithelial cells of tamoxifen-treated mice
increased enterocyte apoptosis ( J:236234 )
• of intestinal epithelial cells in tamoxifen-treated mice
abnormal enterocyte proliferation ( J:236234 )
• reduced proliferation of intestinal epithelial cells in tamoxifen-treated mice

cellular
increased enterocyte apoptosis ( J:236234 )
• of intestinal epithelial cells in tamoxifen-treated mice
abnormal enterocyte proliferation ( J:236234 )
• reduced proliferation of intestinal epithelial cells in tamoxifen-treated mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory