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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf4tm1.2Lwd
targeted mutation 1.2, Mark Lewandoski
MGI:5888998
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Fgf3tm1Lwd/Fgf3tm1Lwd
Fgf4tm1.1Lwd/Fgf4tm1.2Lwd 		involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J MGI:5889000


Genotype
MGI:5889000
cx1
Allelic
Composition		 Fgf3tm1Lwd/Fgf3tm1Lwd
Fgf4tm1.1Lwd/Fgf4tm1.2Lwd
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6 * NIH Swiss Webster * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf3tm1Lwd mutation (1 available); any Fgf3 mutation (16 available)
Fgf4tm1.1Lwd mutation (1 available); any Fgf4 mutation (30 available)
Fgf4tm1.2Lwd mutation (0 available); any Fgf4 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
short rostral-caudal axis ( J:229949 )
• defects in the caudal axis extension
abnormal presomitic mesoderm morphology ( J:229949 )
• decreased length of tailbud presomitic mesoderm as compared to controls

limbs/digits/tail
decreased caudal vertebrae number ( J:229949 )
• decreased number of caudal vertebrae at E18.5

skeleton
decreased caudal vertebrae number ( J:229949 )
• decreased number of caudal vertebrae at E18.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory