Analysis Tools
reproductive system
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• loss of oocytes perinatally or soon after birth
• oocytes present in ovaries of fetal and newborn mice but absent at 6 week old
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• low Msh4 foci numbers in late zygotene-pachytene spermatocytes and oocytes
• lack of Mlh1 foci in spermatocytes and oocytes
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• chromosome axes unaligned and mostly unsynapsed in late zygotene-pachytene in spermatocytes
• unsynapsed or low level synapsed chromosome axes in 55% of early and 41% of late pachytene oocytes
• 53% of synaptonemal complex stretches were non-homologous in spermatocytes
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• atrophic, barely discernible and completely devoid of oocytes at 6 weeks old
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• absence of late prophase spermatocytes and postmeiotic cells
• apoptosis of spermatocytes in epithelial cycle stage IV testis tubules
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azoospermia
(
J:236226
)
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• arrest at the mid-pachytene stage
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cellular
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• loss of oocytes perinatally or soon after birth
• oocytes present in ovaries of fetal and newborn mice but absent at 6 week old
|
azoospermia
(
J:236226
)
|
|
|
|
• low Msh4 foci numbers in late zygotene-pachytene spermatocytes and oocytes
• lack of Mlh1 foci in spermatocytes and oocytes
|
|
|
• arrest at the mid-pachytene stage
|
|
• chromosome axes unaligned and mostly unsynapsed in late zygotene-pachytene in spermatocytes
• unsynapsed or low level synapsed chromosome axes in 55% of early and 41% of late pachytene oocytes
• 53% of synaptonemal complex stretches were non-homologous in spermatocytes
|
|
• high Rad51 and Dmc1 foci numbers in late zygotene-pachytene spermatocytes and late pachytene oocytes
• delayed meiotic double-strand break repair
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homeostasis/metabolism
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• high Rad51 and Dmc1 foci numbers in late zygotene-pachytene spermatocytes and late pachytene oocytes
• delayed meiotic double-strand break repair
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endocrine/exocrine glands
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• atrophic, barely discernible and completely devoid of oocytes at 6 weeks old
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