About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddrgk1tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:5896836
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ 		involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N MGI:5897612


Genotype
MGI:5897612
cn1
Allelic
Composition		 Ddrgk1tm1c(EUCOMM)Hmgu/Ddrgk1tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N
Cell Lines HEPD0618_2_D02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddrgk1tm1c(EUCOMM)Hmgu mutation (0 available); any Ddrgk1 mutation (21 available)
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:231701 )
• 3 weeks after tamoxifen treatment

hematopoietic system
abnormal embryonic erythropoiesis ( J:231701 )
• tamoxifen-treated mice exhibit impaired erythroid development at multiple stages
decreased erythrocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased hemoglobin content ( J:231701 )
• after tamoxifen treatment
decreased granulocyte number ( J:231701 )
• after tamoxifen treatment
decreased lymphocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased monocyte cell number ( J:231701 )
• after tamoxifen treatment
pancytopenia ( J:231701 )
• severe in adult mice treated with tamoxifen
abnormal hematopoietic stem cell physiology ( J:231701 )
• cell-autonomous impairment of hematopoietic stem cell function with activation of unfolded protein response and cell death after tamoxifen treatment

embryo
abnormal embryonic erythropoiesis ( J:231701 )
• tamoxifen-treated mice exhibit impaired erythroid development at multiple stages

growth/size/body
weight loss ( J:231701 )
• after tamoxifen treatment

immune system
decreased granulocyte number ( J:231701 )
• after tamoxifen treatment
decreased lymphocyte cell number ( J:231701 )
• after tamoxifen treatment
decreased monocyte cell number ( J:231701 )
• after tamoxifen treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory