Phenotypes associated with this allele

• Allele Symbol: Amtn^tm1Tigm
• Allele Name: targeted mutation 1, Texas Institute for Genomic Medicine
• Allele ID: MGI:5896933
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Amtn^tm1Tigm/Amtn^tm1Tigm	involves: 129S5/SvEvBrd * C57BL/6	MGI:5896994

Genotype
MGI:5896994

hm1

• Allelic Composition: Amtn^tm1Tigm/Amtn^tm1Tigm
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal incisor color ( J:240990 )

abnormal enamel morphology ( J:240990 )

• on specific teeth with mandibular incisors most affected by chalky enamel and lack of typical translucent incisal edge

• starting at 13 weeks, most mice exhibit chipping of mandibular incisors unlike wild-type mice

• however, maxillary incisors and molars exhibit no chipping

abnormal ameloblast morphology ( J:240990 )

• less frequent pigment granules

• however, the structure of ameloblasts and cellular organelles is normal

abnormal enamel mineralization ( J:240990 )

• enamel mineralization is delayed and more gradual than in wild-type mice

• retention of increased organic matrix

growth/size/body

abnormal incisor color ( J:240990 )

abnormal enamel morphology ( J:240990 )

• on specific teeth with mandibular incisors most affected by chalky enamel and lack of typical translucent incisal edge

• starting at 13 weeks, most mice exhibit chipping of mandibular incisors unlike wild-type mice

• however, maxillary incisors and molars exhibit no chipping

abnormal ameloblast morphology ( J:240990 )

• less frequent pigment granules

• however, the structure of ameloblasts and cellular organelles is normal

abnormal enamel mineralization ( J:240990 )

• enamel mineralization is delayed and more gradual than in wild-type mice

• retention of increased organic matrix

skeleton

abnormal incisor color ( J:240990 )

abnormal enamel morphology ( J:240990 )

• on specific teeth with mandibular incisors most affected by chalky enamel and lack of typical translucent incisal edge

• starting at 13 weeks, most mice exhibit chipping of mandibular incisors unlike wild-type mice

• however, maxillary incisors and molars exhibit no chipping

abnormal ameloblast morphology ( J:240990 )

• less frequent pigment granules

• however, the structure of ameloblasts and cellular organelles is normal

abnormal enamel mineralization ( J:240990 )

• enamel mineralization is delayed and more gradual than in wild-type mice

• retention of increased organic matrix