Phenotypes associated with this allele

• Allele Symbol: Tm6sf2^em1Yech
• Allele Name: endonuclease-mediated mutation 1, Y Eugene Chen
• Allele ID: MGI:5896993
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tm6sf2^em1Yech/Tm6sf2^em1Yech	C57BL/6-Tm6sf2^em1Yech	MGI:5897373

Genotype
MGI:5897373

hm1

• Allelic Composition: Tm6sf2^em1Yech/Tm6sf2^em1Yech
• Genetic Background: C57BL/6-Tm6sf2^em1Yech

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:235704 )

N • mice fed a chow diet or a high-fat diet (HFD) show no significant changes in serum alanine aminotransferase or aspartate aminotransferase levels relative to controls

increased circulating triglyceride level ( J:235704 )

• slight but significant increase in plasma triglyceride level in mice fed a normal chow diet

• 28.7% increase in plasma triglyceride level after a 12-week HFD feeding

abnormal cholesterol homeostasis ( J:235704 )

• mice fed a chow diet or a HFD exhibit upregulated liver expression of cholesterol metabolism-related genes relative to controls

decreased circulating cholesterol level ( J:235704 )

• decreased total plasma cholesterol in mice fed a normal chow diet

• total plasma cholesterol level is decreased to 71.2% of control mice after a 12-week HFD feeding

decreased circulating HDL cholesterol level ( J:235704 )

• decreased plasma HDL cholesterol level in mice fed a normal chow diet

• plasma HDL cholesterol level is decreased to 66.3% of control mice after a 12-week HFD feeding

decreased circulating LDL cholesterol level ( J:235704 )

• plasma LDL cholesterol level is decreased to 68.1% of control mice after a 12-week HFD feeding

• however, no significant change is noted on a normal chow diet

liver/biliary system

liver/biliary system phenotype ( J:235704 )

N • mice fed a chow diet or a HFD show no significant changes in liver to body weight ratio, liver histology, liver cholesterol content or liver triglyceride accumulation relative to controls

N • mice fed a HFD for 10-12 weeks show no significant development of liver fibrosis or liver inflammation relative to controls