Phenotypes associated with this allele

• Allele Symbol: Memo1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5896997
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	H2az2^Tg(Wnt1-cre)11Rth/H2az2^+ Memo1^tm1c(EUCOMM)Wtsi/Memo1^tm1c(EUCOMM)Wtsi	involves: C57BL/6 * CBA/J * SJL	MGI:7464191

Genotype
MGI:7464191

cn1

• Allelic Composition: H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺; Memo1^{tm1c(EUCOMM)Wtsi}/Memo1^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * CBA/J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:233609 )

craniofacial

abnormal craniofacial bone morphology ( J:233609 )

wide coronal suture ( J:233609 )

wide metopic suture ( J:233609 )

small basisphenoid bone ( J:233609 )

• mild rostral truncation

presphenoid bone hypoplasia ( J:233609 )

• severely hypoplastic or fails to ossify

• this bone is most severely affected in the single mouse with a visible cleft palate

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

premaxilla hypoplasia ( J:233609 )

palatine bone horizontal plate hypoplasia ( J:233609 )

domed cranium ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped

behavior/neurological

absent gastric milk in neonates ( J:233609 )

• despite absence of cleft palate in most pups

digestive/alimentary system

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

palatine bone horizontal plate hypoplasia ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

skeleton

abnormal craniofacial bone morphology ( J:233609 )

wide coronal suture ( J:233609 )

wide metopic suture ( J:233609 )

small basisphenoid bone ( J:233609 )

• mild rostral truncation

presphenoid bone hypoplasia ( J:233609 )

• severely hypoplastic or fails to ossify

• this bone is most severely affected in the single mouse with a visible cleft palate

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

premaxilla hypoplasia ( J:233609 )

palatine bone horizontal plate hypoplasia ( J:233609 )

domed cranium ( J:233609 )

abnormal endochondral bone ossification ( J:233609 )

• hyoid fails to ossify

growth/size/body

maxillary shelf hypoplasia ( J:233609 )

• not as severely affected as the palatine bone

palatine bone horizontal plate hypoplasia ( J:233609 )

cleft palate ( J:233609 )

• unlike in mice homozygous for Memo1^m1Will only a single pup ot of 10 showed a cleft palate

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped

respiratory system

abnormal nasal bridge morphology ( J:233609 )

• slightly dipped