All Phenotypes Opn3<tm2b(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Opn3^{tm2b(EUCOMM)Wtsi}
targeted mutation 2b, Wellcome Trust Sanger Institute
MGI:5897190

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi}	involves: C57BL/6N * FVB/N	MGI:6457281
cx2	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA	MGI:5897203

Allelic Composition	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2b(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

abnormal beige fat cell morphology ( J:287419 )

• low beige content in inguinal white adipose tissue

abnormal white fat cell size ( J:287419 )

• larger size distribution

abnormal adipose tissue physiology ( J:287419 )

• reduced fat mobilization indicated by increased postmortem fat deposits

homeostasis/metabolism

abnormal homeostasis ( J:287419 )

• mice exhibit normal circadian phasing and respiratory exchange ratio

impaired adaptive thermogenesis ( J:287419 )

• following cold exposure, mice exhibit reduced core body temperature compared with control mice

decreased core body temperature ( J:287419 )

• following cold exposure

decreased energy expenditure ( J:287419 )

• in male mice housed at 10 Celcius

increased carbon dioxide production ( J:287419 )

decreased oxygen consumption ( J:287419 )

• in male mice housed at 10 Celcius

behavior/neurological

decreased fluid intake ( J:287419 )

decreased food intake ( J:287419 )

Allelic Composition	Opn3^{tm2b(EUCOMM)Wtsi}/Opn3^{tm2b(EUCOMM)Wtsi} Per2^tm1Jt/Per2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6N * CBA
Cell Lines	EPD0197_3_E01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Opn3^{tm2b(EUCOMM)Wtsi} mutation (0 available); any Opn3 mutation (25 available)
Per2^tm1Jt mutation (2 available); any Per2 mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:227078 )

N	• retinas exhibit normal circadian photoentrainment and corneal photoentrainment

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