All Phenotypes Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol MGI Mouse

cardiovascular system phenotype ( J:234490 )

N	• mice exhibit normal cardiac growth and chamber dimensions up to 1 year of age

thick interventricular septum ( J:234490 )

• in mice treated with metoprolol

increased heart weight ( J:234490 )

• in mice treated with metoprolol

• following transverse aortic constriction to induce pressure overload

cardiac hypertrophy ( J:234490 )

• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy compared with wild-type mice

increased heart left ventricle size ( J:234490 )

• in mice treated with metoprolol

• following transverse aortic constriction to induce pressure overload

abnormal cardiac muscle contractility ( J:234490 )

• mice treated with metoprolol exhibit no effect on systolic performance unlike wild-type mice

• following transverse aortic constriction to induce pressure overload, mice fail to exhibit an increased in fractional shortening unlike wild-type mice

increased cardiac muscle contractility ( J:234490 )

• despite smaller Ca+2 amplitudes

decreased cardiac muscle relaxation ( J:234490 )

• prolonged relaxation and rate of Ca2+ transient decay

• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol

abnormal myocardial fiber physiology ( J:234490 )

• prolonged time at elevated tension with a set amount of Ca+2

• enhanced myofilament Ca2+ sensitivity

decreased response of heart to induced stress ( J:234490 )

• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy but fail to exhibit an increased in fractional shortening unlike wild-type mice

decreased response of heart to induced stress ( J:234490 )

• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy but fail to exhibit an increased in fractional shortening unlike wild-type mice

decreased physiological sensitivity to xenobiotic ( J:234490 )

• mice treated with metoprolol exhibit no effect on systolic performance with increased left ventricular chamber dimension, septal wall thickness and cardiac mass compared with wild-type mice

• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol

abnormal cardiac muscle contractility ( J:234490 )

• mice treated with metoprolol exhibit no effect on systolic performance unlike wild-type mice

• following transverse aortic constriction to induce pressure overload, mice fail to exhibit an increased in fractional shortening unlike wild-type mice

increased cardiac muscle contractility ( J:234490 )

• despite smaller Ca+2 amplitudes

decreased cardiac muscle relaxation ( J:234490 )

• prolonged relaxation and rate of Ca2+ transient decay

• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol

increased heart weight ( J:234490 )

• in mice treated with metoprolol

• following transverse aortic constriction to induce pressure overload

cardiac hypertrophy ( J:234490 )

• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy compared with wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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