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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol
transgene insertion 2, Jeffery Molkentin
MGI:5897318
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Atp2a2tm1Ges/Atp2a2+
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0
Tg(Myh6-tTA)55Rbns/0
involves: 129X1/SvJ * FVB MGI:5897401
cx2
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0
Tg(Myh6-tTA)55Rbns/0
involves: FVB MGI:5897387


Genotype
MGI:5897401
cx1
Allelic
Composition
Atp2a2tm1Ges/Atp2a2+
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background
involves: 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2a2tm1Ges mutation (1 available); any Atp2a2 mutation (76 available)
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• compared to in Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mice
• more so than in Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mice
• increased left ventricle wall thickness compared to in Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mice
• increased unloaded twitch force

growth/size/body
• more so than in Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mice




Genotype
MGI:5897387
cx2
Allelic
Composition
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol/0
Tg(Myh6-tTA)55Rbns/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6/tetO-Tnnc1*L48Q)2Jmol mutation (1 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• mice exhibit normal cardiac growth and chamber dimensions up to 1 year of age
• in mice treated with metoprolol
• in mice treated with metoprolol
• following transverse aortic constriction to induce pressure overload
• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy compared with wild-type mice
• in mice treated with metoprolol
• following transverse aortic constriction to induce pressure overload
• mice treated with metoprolol exhibit no effect on systolic performance unlike wild-type mice
• following transverse aortic constriction to induce pressure overload, mice fail to exhibit an increased in fractional shortening unlike wild-type mice
• despite smaller Ca+2 amplitudes
• prolonged relaxation and rate of Ca2+ transient decay
• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol
• prolonged time at elevated tension with a set amount of Ca+2
• enhanced myofilament Ca2+ sensitivity
• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy but fail to exhibit an increased in fractional shortening unlike wild-type mice

homeostasis/metabolism
• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy but fail to exhibit an increased in fractional shortening unlike wild-type mice
• mice treated with metoprolol exhibit no effect on systolic performance with increased left ventricular chamber dimension, septal wall thickness and cardiac mass compared with wild-type mice
• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol

muscle
• mice treated with metoprolol exhibit no effect on systolic performance unlike wild-type mice
• following transverse aortic constriction to induce pressure overload, mice fail to exhibit an increased in fractional shortening unlike wild-type mice
• despite smaller Ca+2 amplitudes
• prolonged relaxation and rate of Ca2+ transient decay
• however, mice exhibit normal relaxation time and Ca2+ decay time whether treated with isopropynol

growth/size/body
• in mice treated with metoprolol
• following transverse aortic constriction to induce pressure overload
• following transverse aortic constriction to induce pressure overload, mice exhibit increased hypertrophy compared with wild-type mice





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory