Analysis Tools
mortality/aging
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• 6 of 18 mice die at P0
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• 4 of 18 mice die by P2
• however, mice exhibit normal survival beyond P2
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• fewer than expected mice are present at E18.5
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reproductive system
azoospermia
(
J:230053
)
|
• in some mice
• however, some mice exhibit normal mature spermatozoa
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• variable testicular vacuolation
• mice exhibit accumulation of disordered proteins in the testes unlike wild-type mice
• however, mice exhibit normal epithelium and interstitial Leydig cells
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• degeneration and atrophic ranging from mild and focal vacuolation of the basal layer of spermatogonia to a marked decrease in tubule diameter with diffuse tubular atrophy, vacuolation of the basal layer of spermatogonia
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cellular
| N |
• mouse embryonic fibroblasts exhibit normal cell tolerability to DNA interstrand cross-linking
• skin-derived fibroblasts exhibit normal response to various cytotoxic stressors
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azoospermia
(
J:230053
)
|
• in some mice
• however, some mice exhibit normal mature spermatozoa
|
integument
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• at P0, more distinct cell borders granules in the granular cell layer compared to in wild-type mice
• however, adult mice exhibit normal epidermal structure
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• at P0, dorsal skin exhibits loss of granules in the granular cell layer compared with wild-type mice
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endocrine/exocrine glands
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• variable testicular vacuolation
• mice exhibit accumulation of disordered proteins in the testes unlike wild-type mice
• however, mice exhibit normal epithelium and interstitial Leydig cells
|
|
• degeneration and atrophic ranging from mild and focal vacuolation of the basal layer of spermatogonia to a marked decrease in tubule diameter with diffuse tubular atrophy, vacuolation of the basal layer of spermatogonia
|
hematopoietic system
immune system
