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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smarca4mos6
modifier of Sox10 6
MGI:5898019
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smarca4mos6/Smarca4mos6 involves: BALB/cJ * C57BL/6J MGI:6241341
cx2
 		Smarca4mos6/Smarca4+
Sox10tm1Weg/Sox10+ 		involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:6241342


Genotype
MGI:6241341
hm1
Allelic
Composition		 Smarca4mos6/Smarca4mos6
Genetic
Background		 involves: BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4mos6 mutation (0 available); any Smarca4 mutation (110 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:241206 )
• no homozygous embryos are recovered at E9.5 or later time points




Genotype
MGI:6241342
cx2
Allelic
Composition		 Smarca4mos6/Smarca4+
Sox10tm1Weg/Sox10+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4mos6 mutation (0 available); any Smarca4 mutation (110 available)
Sox10tm1Weg mutation (1 available); any Sox10 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:241206 )
• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10tm1Weg heterozygotes
head spot ( J:241206 )
• adult double heterozygous mice exhibit a head spot

integument
belly spot ( J:241206 )
• adult double heterozygous mice exhibit more severe ventral white spotting than typically observed in single Sox10tm1Weg heterozygotes
head spot ( J:241206 )
• adult double heterozygous mice exhibit a head spot

embryo
abnormal melanoblast morphology ( J:241206 )
• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10tm1Weg heterozygotes

nervous system
abnormal melanoblast morphology ( J:241206 )
• at E13.5, double heterozygous mice show a significant reduction of cranial melanoblast numbers relative to single Sox10tm1Weg heterozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory