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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(RP11-H2112)5Trme
transgene insertion 5, Trevelyan R Menheniott
MGI:5898085
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Il6sttm1Ern/Il6sttm1Ern
Tg(RP11-H2112)5Trme/0
involves: 129S1/Sv * C57BL/6J * DBA/2J MGI:5898091


Genotype
MGI:5898091
cx1
Allelic
Composition
Il6sttm1Ern/Il6sttm1Ern
Tg(RP11-H2112)5Trme/0
Genetic
Background
involves: 129S1/Sv * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6sttm1Ern mutation (13 available); any Il6st mutation (80 available)
Tg(RP11-H2112)5Trme mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• decrease in the overall thickness of the antral mucosa compared to mice homozygous for the Il6st mutation not carrying the transgene
• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

hematopoietic system
• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene

neoplasm
• decrease in antral tumor growth compared to mice homozygous for the Il6st mutation not carrying the transgene suggesting overexpression of GNK2 as a possible therapy for gastric cancer

immune system
• decrease in the splenomegaly phenotype typically seen in mice homozygous for the Il6st mutation not carrying the transgene





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory