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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MahlC57BL/6J
C57BL/6J
MGI:5898294
Summary 2 genotypes


Genotype
MGI:5898367
cx1
Allelic
Composition		 Cdh23ahl/Cdh23ahl
MahlC57BL/6J/MahlC57BL/6J
Genetic
Background		 129S1.B6-(rs3696307-rs257098870)/Kjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23ahl mutation (55 available); any Cdh23 mutation (281 available)
MahlC57BL/6J mutation (1 available); any Mahl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear hair cell degeneration ( J:241137 )
• progressive inner and outer hair cell loss occur as a result of the age related hearing loss mutation, but in the presence of the ameliorating C57BL/6J allele of Mahl the cochlear hair cell loss on this 129S1 congenic background is less severe at 9 months of age than it is at 6 months of age in mice homozygous for the 129S1/SvImJ allele of Mahl
increased or absent threshold for auditory brainstem response ( J:241137 )
• The age related hearing loss allele causes elevated ABR thresholds relative to the 129S1 host background, but this is partially ameliorated by the presence of the C57BL/6J allele of Mahl

nervous system
cochlear hair cell degeneration ( J:241137 )
• progressive inner and outer hair cell loss occur as a result of the age related hearing loss mutation, but in the presence of the ameliorating C57BL/6J allele of Mahl the cochlear hair cell loss on this 129S1 congenic background is less severe at 9 months of age than it is at 6 months of age in mice homozygous for the 129S1/SvImJ allele of Mahl




Genotype
MGI:5898375
cx2
Allelic
Composition		 Cdh23ahl/Cdh23tm1.1Kjn
MahlC57BL/6J/Mahl129S1/SvImJ
Genetic
Background		 (129S1.B6-(rs3696307-rs257098870)/Kjn x 129S/Sv-Cdh23tm1.1Kjn/Kjn)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh23ahl mutation (55 available); any Cdh23 mutation (281 available)
Cdh23tm1.1Kjn mutation (1 available); any Cdh23 mutation (281 available)
Mahl129S1/SvImJ mutation (1 available); any Mahl mutation (2 available)
MahlC57BL/6J mutation (1 available); any Mahl mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased or absent threshold for auditory brainstem response ( J:241137 )
• these mice, homozygous for the c.735A point mutation that causes age related hearing loss and heterozgyous for the ameliorating C57BL/6J-derived modifier, have a 16 kHz ABR threshold at 3 months of age that is less than mice homozygous for the 129S1/SvImJ-derived modifier, proving the C57BL/6J allele dominant




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/02/2024
MGI 6.13 		The Jackson Laboratory