Analysis Tools
reproductive system
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• ovaries contained few or no developing primary follicles
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small testis
(
J:240463
)
|
• lumina of seminiferous tubules largely devoid of maturing sperm
• caudal epididymis contains few if any mature spermatids
• there are normal numbers of diplotene spermatocytes
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• reduced numbers of pachytene stage cells and increase in the number of abnormal pachytene-like cells with irregular synapses
• reduction in the number of metaphase I cells
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• irregular synaptic behavior including gaps, breaks and entangled chromosomes
• reduced ability to synapse homologous chromosomes
• reduced crossing-over between homologous chromosomes
• reduced number of Dmc1 foci in late zygotene and early pachytene spermatocytes
• spermatocytes form a proper sex body and there are a normal number of Mlh1 foci in spermatocytes
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• sevenfold reduction
• fewer and smaller litters
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• threefold reduction
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homeostasis/metabolism
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• increase in chromosomal aberrations in primary B cells treated with Parp inhibitor olaparib compromised homologous recombination-mediated double-strand break repair in both meiotic and mitotically growing cells
• reduction in markers of double-strand break repair following induction of breaks in MEFs
|
|
• mice exposed to whole-body ionizing radiation showed an approximately two-fold survival decrease in both sexes
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endocrine/exocrine glands
|
• ovaries contained few or no developing primary follicles
|
small testis
(
J:240463
)
|
• lumina of seminiferous tubules largely devoid of maturing sperm
• caudal epididymis contains few if any mature spermatids
• there are normal numbers of diplotene spermatocytes
|
mortality/aging
|
• mice exposed to whole-body ionizing radiation showed an approximately two-fold survival decrease in both sexes
|
immune system
| N |
• normal splenic B cell numbers, frequencies and proliferation
• normal B cell class-switching to IgG1 and IgG3
• no differences in IgG1, IgG3 or IgM levels in blood serum
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cellular
| N |
• primary MEFs proliferated normally
|
|
• irregular synaptic behavior including gaps, breaks and entangled chromosomes
• reduced ability to synapse homologous chromosomes
• reduced crossing-over between homologous chromosomes
• reduced number of Dmc1 foci in late zygotene and early pachytene spermatocytes
• spermatocytes form a proper sex body and there are a normal number of Mlh1 foci in spermatocytes
|
|
• persistence of Trp53bp1 foci in MEFs after subjection to ionizing radiation
|
|
• increase in chromosomal aberrations in primary B cells treated with Parp inhibitor olaparib compromised homologous recombination-mediated double-strand break repair in both meiotic and mitotically growing cells
• reduction in markers of double-strand break repair following induction of breaks in MEFs
|
