Phenotypes associated with this allele

• Allele Symbol: Gria3^em1Wthg
• Allele Name: endonuclease-mediated mutation 1, Benjamin Davies
• Allele ID: MGI:5898442
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Gria3^em1Wthg/Y	C57BL/6-Gria3^em1Wthg	MGI:6401160

Genotype
MGI:6401160

ot1

• Allelic Composition: Gria3^em1Wthg/Y
• Genetic Background: C57BL/6-Gria3^em1Wthg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal sleep pattern ( J:250314 )

♂ • mice show fewer bouts of brief activity and a decrease in brief bouts of sleep

♂ • however, no differences in the total daily levels of activity or sleep are seen and circadian rhythms remain robust

♂ • mice show enhanced period lengthening under constant light, suggesting increased sensitivity to light

nervous system

abnormal miniature excitatory postsynaptic currents ( J:250314 )

♂ • cumulative frequency distributions of mEPSC amplitudes in cerebellar Purkinje cells show a reduction in large amplitude mEPSCs

♂ • the frequency of mEPSCs in Purkinje neurons is reduced