Phenotypes associated with this allele

• Allele Symbol: Zeb1^tm1.2Mpst
• Allele Name: targeted mutation 1.2, Marc Stemmler
• Allele ID: MGI:5901940
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zeb1^tm1.2Mpst/Zeb1^tm1.2Mpst	involves: C57BL/6 * CBA	MGI:5903305

Genotype
MGI:5903305

hm1

• Allelic Composition: Zeb1^tm1.2Mpst/Zeb1^tm1.2Mpst
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:239147 )

• pups are either stillborn or die shortly after birth

respiratory system

respiratory failure ( J:239147 )

• pups fail to initiate breathing

growth/size/body

fetal growth retardation ( J:239147 )

• general growth retardation at E15.5 and P0

cardiovascular system

abnormal cranial blood vasculature morphology ( J:239147 )

• malformed blood vessels are first noted in the head at E11.5

hemorrhage ( J:239147 )

• small hemorrhages are first noted in the head at E11.5

• hemorrhages are observed at several sites at E15.5 and P0

• 28% of mice exhibit hemorrhages at E14.5-P0

• 37.5% of mice exhibit hemorrhages at E13.5

homeostasis/metabolism

edema ( J:239147 )

• 62.5% of mice exhibit edema at E13.5

• no edema is observed at earlier embryonic stages

hydrops fetalis ( J:239147 )

• 64% of mice exhibit edema at E14.5-P0

vision/eye

cyclopia ( J:239147 )

• lack of one eye at E15.5

limbs/digits/tail

abnormal hindlimb morphology ( J:239147 )

• stooped legs at P0

curly tail ( J:239147 )

• 84% of mice exhibit a curly tail at E14.5-P0

• only 25% of mice exhibit a curly tail at E13.5

• no curly tail is observed at earlier embryonic stages