muscle
reproductive system
• no individuals are detected with more than 80% of mitochondria harboring the mutation without an increase in embryo death
|
growth/size/body
• in male, but not female, mice
|
• in female and male mice, especially at high mutation levels
|
• in male, but not female, mice
|
• in male, but not female, mice
|
cellular
• cells exhibit a selection against high mutation levels in proliferating tissues
• impaired mitochondrial translation
|
• defective in cells from a variety of tissues
• defective at 20 weeks in epithelial cells of colonic crypts
• defective at 40 weeks or older in smooth muscle surrounding the colon with greater than 60% of the nutation and occasionally in cardiomyocytes
|
• impaired mitochondrial translation
|
cardiovascular system
• in female and male mice, especially at high mutation levels
|
adipose tissue
• in male, but not female, mice
|
homeostasis/metabolism
• impaired mitochondrial translation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
mitochondrial metabolism disease | DOID:700 | J:238994 |