Phenotypes associated with this allele

• Allele Symbol: Rhox13^tm1.2Chge
• Allele Name: targeted mutation 1.2, Christopher B Geyer
• Allele ID: MGI:5902138
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Rhox13^tm1.2Chge/Y	B6NCrl.129P2(Cg)-Rhox13^tm1.2Chge	MGI:5902151
ot2	Rhox13^tm1.2Chge/Y	involves: 129P2/OlaHsd * C57BL/6N	MGI:5902077

Genotype
MGI:5902151

ot1

• Allelic Composition: Rhox13^tm1.2Chge/Y
• Genetic Background: B6NCrl.129P2(Cg)-Rhox13^tm1.2Chge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased male germ cell number ( J:237048 )

♂ • 3.8-fold reduction in the number of round spermatids per area of seminiferous tubules and an apparent difference in the number of tubules containing round spermatids at P20

♂ • normal numbers of round spermatids at P22

oligozoospermia ( J:237048 )

♂ • 40% reduced number of cauda epididymal sperm in virgin males at P56

♂ • normal numbers of cauda epididymal sperm in breeding males at P120

increased male germ cell apoptosis ( J:237048 )

♂ • approximately three-fold increase in cleaved-Parp1-positive (apoptotic) germ cells at P12 and P20

reproductive system

decreased male germ cell number ( J:237048 )

♂ • 3.8-fold reduction in the number of round spermatids per area of seminiferous tubules and an apparent difference in the number of tubules containing round spermatids at P20

♂ • normal numbers of round spermatids at P22

oligozoospermia ( J:237048 )

♂ • 40% reduced number of cauda epididymal sperm in virgin males at P56

♂ • normal numbers of cauda epididymal sperm in breeding males at P120

increased male germ cell apoptosis ( J:237048 )

♂ • approximately three-fold increase in cleaved-Parp1-positive (apoptotic) germ cells at P12 and P20

Genotype
MGI:5902077

ot2

• Allelic Composition: Rhox13^tm1.2Chge/Y
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

reproductive system

decreased male germ cell number ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

oligozoospermia ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

increased male germ cell apoptosis ( J:237048 )

♂ • Background Sensitivity: many vacuolated spaces within the seminiferous epithelia of tubules

abnormal seminiferous tubule epithelium morphology ( J:237048 )

♂ • Background Sensitivity: missing layers of spermatogenic cells, including basal spermatogonia or adluminal spermatocytes and spermatids

abnormal fertility/fecundity ( J:237048 )

♂ • Background Sensitivity: increase in the time between litters sired by knockout males

♂ • normal breeding behavior, average numbers of pups per litter and time to birth of first litter

cellular

decreased male germ cell number ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

oligozoospermia ( J:237048 )

♂ • Background Sensitivity: some mice, presumably those with more 129 strain background, had extremely low cauda sperm counts

increased male germ cell apoptosis ( J:237048 )

♂ • Background Sensitivity: many vacuolated spaces within the seminiferous epithelia of tubules

endocrine/exocrine glands

abnormal seminiferous tubule epithelium morphology ( J:237048 )

♂ • Background Sensitivity: missing layers of spermatogenic cells, including basal spermatogonia or adluminal spermatocytes and spermatids