nervous system
behavior/neurological
N |
• no abnormal activity level or motor impairment
|
cardiovascular system
• retinal vaculature becomes attenuated with age
|
pigmentation
vision/eye
• the retina has a grainy appearance with light spots
|
• retinal vaculature becomes attenuated with age
|
• although normal thickness at 1 month of age, the retina is 47% thinner than normal at 12 months
|
• the a-wave of homozygotes declines rapidly between 3 and 4 months of age, being decreased by 83% at 12 months of age, which is a slower loss than that found in imh (V9M) homozygotes
|
• light-adapted ERG shows a diminution of the b-wave by 6 months of age and this gets worse with age, but is a later onset than that caused by the imh (V9M) point mutation
|
• dark-adapted ERG shows a diminution of the b-wave by 4 months of age and this gets worse with age, but is a later onset than that caused by the imh (V9M) point mutation
|
growth/size/body
N |
• normal size and weight
|
mortality/aging
N |
• normal lifespan
|
reproductive system
N |
• normal fertility
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
retinal degeneration | DOID:8466 | J:234111 |