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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nmnat1tvrm113
translational vision research model 113
MGI:5902788
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nmnat1tvrm113/Nmnat1tvrm113 C57BL/6J-Nmnat1tvrm113/Pjn MGI:5903076


Genotype
MGI:5903076
hm1
Allelic
Composition
Nmnat1tvrm113/Nmnat1tvrm113
Genetic
Background
C57BL/6J-Nmnat1tvrm113/Pjn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat1tvrm113 mutation (1 available); any Nmnat1 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

behavior/neurological
N
• no abnormal activity level or motor impairment

cardiovascular system
• retinal vaculature becomes attenuated with age

pigmentation

vision/eye
• the retina has a grainy appearance with light spots
• retinal vaculature becomes attenuated with age
• although normal thickness at 1 month of age, the retina is 47% thinner than normal at 12 months
• the a-wave of homozygotes declines rapidly between 3 and 4 months of age, being decreased by 83% at 12 months of age, which is a slower loss than that found in imh (V9M) homozygotes
• light-adapted ERG shows a diminution of the b-wave by 6 months of age and this gets worse with age, but is a later onset than that caused by the imh (V9M) point mutation
• dark-adapted ERG shows a diminution of the b-wave by 4 months of age and this gets worse with age, but is a later onset than that caused by the imh (V9M) point mutation

growth/size/body
N
• normal size and weight

mortality/aging
N
• normal lifespan

reproductive system
N
• normal fertility

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
retinal degeneration DOID:8466 J:234111





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory