Phenotypes associated with this allele

• Allele Symbol: Cic^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:5903084
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cic^tm1c(KOMP)Wtsi/Cic^tm1c(KOMP)Wtsi Neurod6^tm1(cre)Kan/Neurod6^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N	MGI:6275615
cn2	Cic^tm1c(KOMP)Wtsi/Cic^tm1c(KOMP)Wtsi Emx1^tm1(cre)Krj/Emx1^+	involves: 129S2/SvPas * C57BL/6 * C57BL/6N	MGI:6275604
cn3	Cic^tm1c(KOMP)Wtsi/Cic^tm1c(KOMP)Wtsi Tg(Otp-cre)1Hzo/0	involves: C57BL/6 * C57BL/6N * FVB/N	MGI:6275616

Genotype
MGI:6275615

cn1

• Allelic Composition: Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi}; Neurod6^tm1(cre)Kan/Neurod6⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased cerebral cortex cell number ( J:240674 )

• mice show a reduction in the number of cells expressing CUX1 and SATB2 in cortical layers 2-4

Genotype
MGI:6275604

cn2

• Allelic Composition: Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi}; Emx1^tm1(cre)Krj/Emx1⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6N

behavior/neurological

impaired contextual conditioning behavior ( J:240674 )

• in a fear conditioning assay, mice exhibit reduced freezing, especially in the test of spatial context, indicating impaired learning and memory

• however, mice show normal social behavior in the three-chamber test

decreased anxiety-related response ( J:240674 )

• in the elevated plus-maze test, mice spend more time in the open arm and less in the closed arm, indicating reduced anxiety

increased locomotor activity ( J:240674 )

• mice cover a greater distance at a greater speed in the open-field test

• mice treated with a low dose of amphetamine show reduced hyperactivity

nervous system

decreased dentate gyrus size ( J:240674 )

• the hippocampal dentate gyrus shows decreased thickness at 20 weeks of age, however the CA1 and CA3 regions are normal

abnormal cerebral cortex morphology ( J:240674 )

• mice exhibit a transient increase of apoptosis in the upper layers of the cortex at P5 that is no longer seen at P10

• however, the corpus callosum appears normal

decreased cerebral cortex cell number ( J:240674 )

• the number of CUX1+ neurons in layers 2-4 is reduced at 5 weeks

• numbers of CUX1+ and SATB2+ neurons in layers 2-4 of the cortex are normal at P0 but decline postnatally and by P10 are comparable to that at 5 weeks

• the numbers of progenitors and their proliferation rates in embryonic cortex are not different from wild-type

thin cerebral cortex ( J:240674 )

• mice show reduced thickness of cortical layers 2-4 at 5 and 20 weeks of age, whereas thickness of layers 5 and 6 remains normal

abnormal pyramidal neuron dendrite morphology ( J:240674 )

• layer 2/3 pyramidal neurons show reduced dendritic branching complexity in 5 week old mice

• however, layer 5 pyramidal neurons show normal dendritic branching

decreased neurotransmitter release ( J:240674 )

• mice show a decrease in the probability of presynaptic neurotransmitter release

• however, basal synaptic transmission and long-term synaptic plasticity are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
disease of mental health		DOID:150		J:240674

Genotype
MGI:6275616

cn3

• Allelic Composition: Cic^{tm1c(KOMP)Wtsi}/Cic^{tm1c(KOMP)Wtsi}; Tg(Otp-cre)1Hzo/0
• Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

behavior/neurological

increased aggression towards mice ( J:240674 )

• in the resident-intruder test, mice behave more aggressively toward intruders, with more frequent and longer attack episodes

abnormal social investigation ( J:240674 )

• in the three-chamber test, mice interact less with other mice

• however, mice do not exhibit abnormal behavior in the open-field, elevated plus-maze, or fear conditioning assay

abnormal response to social novelty ( J:240674 )

• in the partition test, mice spend less time interacting with novel mice

nervous system

nervous system phenotype ( J:240674 )

N • no gross abnormalities or altered cellularity of Otp-lineage neurons are seen