immune system
• increased numbers of medullary thymocytes
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• in spleen, lymph nodes and bone marrow
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• immature Cd23- and Cd23+ cells in the spleen were unaffected
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• in the spleen
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• significantly reduced in lymph nodes
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• in the spleen
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• in the spleen
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• incompletely developed
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• in the spleen
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• noncanonical Nfkb pathway signaling was absent after in vitro stimulation with anti-Cd40 antibody
• induction of the canonical pathway (as assessed by Nfkbib degradation) was unaffected after in vitro stimulation with anti-Cd40 antibody
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hematopoietic system
• increased numbers of medullary thymocytes
|
• in spleen, lymph nodes and bone marrow
|
• immature Cd23- and Cd23+ cells in the spleen were unaffected
|
• in the spleen
|
• significantly reduced in lymph nodes
|
• in the spleen
|
• in the spleen
|
• incompletely developed
|
• in the spleen
|
• noncanonical Nfkb pathway signaling was absent after in vitro stimulation with anti-Cd40 antibody
• induction of the canonical pathway (as assessed by Nfkbib degradation) was unaffected after in vitro stimulation with anti-Cd40 antibody
|
endocrine/exocrine glands
• increased numbers of medullary thymocytes
|