Phenotypes associated with this allele

• Allele Symbol: App^tm1.1Wevn
• Allele Name: targeted mutation 1.1, William Van Nostrand
• Allele ID: MGI:5903308
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm1.1Wevn/App^tm1.1Wevn	B6.129S6(FVB)-App^tm1.1Wevn	MGI:5903440

Genotype
MGI:5903440

hm1

• Allelic Composition: App^tm1.1Wevn/App^tm1.1Wevn
• Genetic Background: B6.129S6(FVB)-App^tm1.1Wevn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hematoma ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type and to homozygous null App^tm1Dbo mice

intracerebral hemorrhage ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type and to homozygous null App^tm1Dbo mice

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:241632 )

• time to cessation of blood flow following induced carotid artery thrombosis is decreased as compared to wild-type mice; however, vessel occlusion is slightly, yet significantly, faster in homozygous null App^tm1Dbo mice

nervous system

intracerebral hemorrhage ( J:241632 )

• hematomas are smaller following experimentally induced intracerebral hemorrhage as compared to wild-type and to homozygous null App^tm1Dbo mice