About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zscan21tm1.1Jiwa
targeted mutation 1.1, Jiaxiang Wang
MGI:5904160
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(Stra8-icre)1Reb/0
Zscan21tm1.1Jiwa/Zscan21tm1.1Jiwa 		involves: FVB/NJ MGI:5904161


Genotype
MGI:5904161
cn1
Allelic
Composition		 Tg(Stra8-icre)1Reb/0
Zscan21tm1.1Jiwa/Zscan21tm1.1Jiwa
Genetic
Background		 involves: FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Stra8-icre)1Reb mutation (2 available)
Zscan21tm1.1Jiwa mutation (0 available); any Zscan21 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatid morphology ( J:237046 )
• testes show no round spermatids
abnormal spermatocyte morphology ( J:237046 )
• testes show few spermatocytes, without round spermatids
abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )
• unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis
arrest of male meiosis ( J:237046 )
• spermatocytes do not progress to meiotic prophase I
decreased testis weight ( J:237046 )
• testis weight of adult males is less than 40% of heterozygotes
male infertility ( J:237046 )
• males are infertile, with 6-8 week old males failing to produce offspring after natural mating with wild-type females for more than 4 months

cellular
abnormal spermatid morphology ( J:237046 )
• testes show no round spermatids
abnormal spermatocyte morphology ( J:237046 )
• testes show few spermatocytes, without round spermatids
abnormal X-Y chromosome synapsis during male meiosis ( J:237046 )
• unsynapsed or partially synapsed chromosomes are seen in spermatocytes indicating failure of chromosomal synapsis
arrest of male meiosis ( J:237046 )
• spermatocytes do not progress to meiotic prophase I
abnormal double-strand DNA break repair ( J:237046 )
• failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci

endocrine/exocrine glands
decreased testis weight ( J:237046 )
• testis weight of adult males is less than 40% of heterozygotes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:237046 )
• failure of double-strand DNA break repair in spermatocytes as indicated by reduced MLH1 foci and RAD51 foci




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory