Phenotypes associated with this allele

• Allele Symbol: Gorasp2^tm1.1Maal
• Allele Name: targeted mutation 1.1, Michel Aurrand-Lions
• Allele ID: MGI:5904163
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal	B6J.129S2(Cg)-Gorasp2^tm1.1Maal	MGI:5904165

Genotype
MGI:5904165

hm1

• Allelic Composition: Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal
• Genetic Background: B6J.129S2(Cg)-Gorasp2^tm1.1Maal

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defective spermatogenesis and acrosome formation in Gorasp2^tm1.1Maal/Gorasp2^tm1.1Maal mice

growth/size/body

postnatal growth retardation ( J:241919 )

• mice exhibit growth retardation

reproductive system

abnormal sperm midpiece morphology ( J:241919 )

♂ • bent midpiece

oligozoospermia ( J:241919 )

♂ • a trend towards reduced sperm counts isolated from the epididymis

abnormal sperm head morphology ( J:241919 )

♂

abnormal acrosome morphology ( J:241919 )

♂ • abnormal acrosome formation

abnormal spermatocyte morphology ( J:241919 )

♂ • enlarged Golgi are present in pachytene spermatocytes of stage II-III seminiferous tubules

asthenozoospermia ( J:241919 )

♂

abnormal spermiogenesis ( J:241919 )

♂ • epididymis contains rare abnormal cells with large nuclei indicating that spermiogenesis is affected

male infertility ( J:241919 )

♂

cellular

abnormal sperm midpiece morphology ( J:241919 )

♂ • bent midpiece

oligozoospermia ( J:241919 )

♂ • a trend towards reduced sperm counts isolated from the epididymis

abnormal sperm head morphology ( J:241919 )

♂

abnormal acrosome morphology ( J:241919 )

♂ • abnormal acrosome formation

abnormal spermatocyte morphology ( J:241919 )

♂ • enlarged Golgi are present in pachytene spermatocytes of stage II-III seminiferous tubules

abnormal Golgi apparatus morphology ( J:241919 )

♂ • increase in Golgi apparatus of germ cells with areas greater than 5 um² in stage II-IV seminiferous tubules

♂ • enlarged Golgi are present in pachytene spermatocytes of stage II-III seminiferous tubules

♂ • primary mouse embryonic fibroblasts from embryos exhibit enlarged Golgi ribbons, with a 2-fold reduction in Golgi density

asthenozoospermia ( J:241919 )

♂