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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt10atm1Smr
targeted mutation 1, Sarah E Millar
MGI:5904666
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
Wnt10atm1Smr/Wnt10atm1Smr 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:5905988
cn2
 		Wnt10atm1Smr/Wnt10atm1Smr
Tg(KRT14-cre)#Smr/0 		involves: 129X1/SvJ * C57BL/6J * SJL/J MGI:5905987


Genotype
MGI:5905988
cn1
Allelic
Composition		 Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
Wnt10atm1Smr/Wnt10atm1Smr
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-rtTA)#Glk mutation (0 available)
Tg(tetO-cre)1Jaw mutation (6 available)
Wnt10atm1Smr mutation (0 available); any Wnt10a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
enlarged sebaceous gland ( J:242196 )
• when treated with doxycycline at P25
abnormal sweat gland morphology ( J:242196 )
• fail to extend when treated with doxycycline in early postnatal life
• regression of sweat glands when treated with doxycycline at P20
abnormal sebaceous lipid secretion ( J:242196 )
• elevated lipid production when treated with doxycycline at P25
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20
small hair follicles ( J:242196 )
• minitaturized when treated with doxycycline at P25
abnormal hair cycle anagen phase ( J:242196 )
• delayed initiation of anagen until P29, when treated with doxycycline at P18
accelerated hair follicle regression ( J:242196 )
• premature when treated with doxycycline at P9
• however, hair follicle regression isnt observed when treated with doxycycline at P25
abnormal hair follicle physiology ( J:242196 )
• slightly reduced proliferation when treated with doxycycline at P25

craniofacial
abnormal tongue morphology ( J:242196 )
• flattened surface when treated with doxycycline in early postnatal life
abnormal filiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal fungiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal gustatory papilla taste bud morphology ( J:242196 )
• miniaturized when treated with doxycycline in early postnatal life
• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

cellular
decreased cell proliferation ( J:242196 )
• decreased basal cell proliferation in the filiform papillae and plantar epithelium, fungiform and circumvallate taste buds and sweat buds when treated with doxycycline at in either the early postnatal period, or in adult life

taste/olfaction
abnormal gustatory papilla taste bud morphology ( J:242196 )
• miniaturized when treated with doxycycline in early postnatal life
• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

digestive/alimentary system
abnormal tongue morphology ( J:242196 )
• flattened surface when treated with doxycycline in early postnatal life
abnormal filiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal fungiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal gustatory papilla taste bud morphology ( J:242196 )
• miniaturized when treated with doxycycline in early postnatal life
• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life

endocrine/exocrine glands
enlarged sebaceous gland ( J:242196 )
• when treated with doxycycline at P25
abnormal sweat gland morphology ( J:242196 )
• fail to extend when treated with doxycycline in early postnatal life
• regression of sweat glands when treated with doxycycline at P20
abnormal sebaceous lipid secretion ( J:242196 )
• elevated lipid production when treated with doxycycline at P25
hypohidrosis ( J:242196 )
• when treated with doxycycline at P20

growth/size/body
abnormal tongue morphology ( J:242196 )
• flattened surface when treated with doxycycline in early postnatal life
abnormal filiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal fungiform papillae morphology ( J:242196 )
• progressive from P7 when treated with doxycycline in early postnatal life
abnormal gustatory papilla taste bud morphology ( J:242196 )
• miniaturized when treated with doxycycline in early postnatal life
• decreased taste bud in fungiform and circumvallate papillae when treated with doxycycline in early postnatal life




Genotype
MGI:5905987
cn2
Allelic
Composition		 Wnt10atm1Smr/Wnt10atm1Smr
Tg(KRT14-cre)#Smr/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)#Smr mutation (0 available)
Wnt10atm1Smr mutation (0 available); any Wnt10a mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:242196 )
N
• bone density is normal
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

growth/size/body
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars

craniofacial
abnormal molar cusp morphology ( J:242196 )
• molar cusp defects
abnormal molar root morphology ( J:242196 )
• molar root defects
supernumerary molars ( J:242196 )
• ectopic M4 molars




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory