Phenotypes associated with this allele

• Allele Symbol: Clcn7^tm2.1Mjec
• Allele Name: targeted mutation 2.1, Michael Econs
• Allele ID: MGI:5904771
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec	129(Cg)-Clcn7^tm2.1Mjec	MGI:5904837
hm2	Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec	B6.129(Cg)-Clcn7^tm2.1Mjec	MGI:5904833
hm3	Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec	C.129(Cg)-Clcn7^tm2.1Mjec	MGI:5904839
hm4	Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec	D2.129(Cg)-Clcn7^tm2.1Mjec	MGI:5904864

Genotype
MGI:5904837

hm1

• Allelic Composition: Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec
• Genetic Background: 129(Cg)-Clcn7^tm2.1Mjec

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone mineral content ( J:240468 )

• +13% m, unchanged f at 3 months normalized for body weight

• +28% m, +10% f at 6 months normalized for body weight

increased areal bone mineral density ( J:240468 )

• slightly (+5% m, +2% f) at 3 months

• +17% m, +3% f at 6 months

increased trabecular bone volume ( J:240468 )

• +106% m, +96% f at distal femur at 3 months

• +700% m, +400% f at distal femur at 6 months

increased bone trabecula number ( J:240468 )

• +32% m, +27% f at distal femur at 3 months

• +69% m, +29% f at distal femur at 6 months

increased trabecular bone thickness ( J:240468 )

• +13% m, +20% f at distal femur at 3 months

• +65% m, +51% f at distal femur at 6 months

growth/size/body

decreased body weight ( J:240468 )

• slightly (-7% m, -2% f) at 3 months

Genotype
MGI:5904833

hm2

• Allelic Composition: Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec
• Genetic Background: B6.129(Cg)-Clcn7^tm2.1Mjec

skeleton

increased bone mineral content ( J:240468 )

• +4% m, +1% f at 3 months months normalized for body weight

increased areal bone mineral density ( J:240468 )

• slightly (+5% m, +2% f) at 3 months

increased trabecular bone volume ( J:240468 )

• +46% m, +36% f at distal femur at 3 months

increased bone trabecula number ( J:240468 )

• +49% m, +35% f at distal femur at 3 months

growth/size/body

increased body weight ( J:240468 )

• slightly (+4% m, +5% f) at 3 months

Genotype
MGI:5904839

hm3

• Allelic Composition: Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec
• Genetic Background: C.129(Cg)-Clcn7^tm2.1Mjec

skeleton

increased bone mineral content ( J:240468 )

• +7% m, +2% f at 3 months months normalized for body weight

increased areal bone mineral density ( J:240468 )

• slightly (+7% m, +5% f) at 3 months

increased trabecular bone volume ( J:240468 )

• +33% m, +39% f at distal femur at 3 months

increased bone trabecula number ( J:240468 )

• +23% m, +16% f at distal femur at 3 months

increased trabecular bone thickness ( J:240468 )

• unchanged m, +13% f at distal femur at 3 months

growth/size/body

increased body weight ( J:240468 )

• slightly (+5% m, +2% f) at 3 months

Genotype
MGI:5904864

hm4

• Allelic Composition: Clcn7^tm2.1Mjec/Clcn7^tm2.1Mjec
• Genetic Background: D2.129(Cg)-Clcn7^tm2.1Mjec

skeleton

increased bone mineral content ( J:240468 )

• +12% m, +3% f at 3 months normalized for body weight

increased areal bone mineral density ( J:240468 )

• slightly (+4% m, +1% f) at 3 months

increased trabecular bone volume ( J:240468 )

• +92% m, +73% f at distal femur at 3 months

increased bone trabecula number ( J:240468 )

• +37% m, +26% f at distal femur at 3 months

increased trabecular bone thickness ( J:240468 )

• +6% m, +5% f at distal femur at 3 months

growth/size/body

decreased body weight ( J:240468 )

• slightly (-2% m, -4% f) at 3 months