cardiovascular system
• Golgi stack and surrounding transitional vesicles are enlarged and increased in number in 8 week old left ventricular cardiomyocytes
• degenerative myelin figures are seen in both ventricular and atrial cardiomyocytes at 8 weeks of age
• atrial myocytes contain overabundant atrial natriuretic peptide granules
• cardiomyocyte volume is increased by 100% and 13% in cells from left and right ventricles, respectively
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• myocyte size, measured as cell capacitance, is increased indicating hypertrophy
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• cardiac mass is increased already at 6 weeks of age and myocyte size is increased
• expression of hypertrophy-associated genes is increased at 6 weeks of age
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• mice show progressive development of dilated cardiomyopathy after 12-24 weeks of age
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• ventricular myocyte contractile function, measured as either the extent or maximal rate of unloaded shortening is depressed
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• echocardiographic left ventricular fractional shortening progressively deteriorates overtime after 12-24 weeks of age
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• L-type calcium channel current is depressed in myocytes
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• amplitude of calcium transient is normal in ventricular myocytes, but calcium uptake is depressed
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muscle
• Golgi stack and surrounding transitional vesicles are enlarged and increased in number in 8 week old left ventricular cardiomyocytes
• degenerative myelin figures are seen in both ventricular and atrial cardiomyocytes at 8 weeks of age
• atrial myocytes contain overabundant atrial natriuretic peptide granules
• cardiomyocyte volume is increased by 100% and 13% in cells from left and right ventricles, respectively
|
• myocyte size, measured as cell capacitance, is increased indicating hypertrophy
|
• mice show progressive development of dilated cardiomyopathy after 12-24 weeks of age
|
• ventricular myocyte contractile function, measured as either the extent or maximal rate of unloaded shortening is depressed
|
• echocardiographic left ventricular fractional shortening progressively deteriorates overtime after 12-24 weeks of age
|
growth/size/body
• cardiac mass is increased already at 6 weeks of age and myocyte size is increased
• expression of hypertrophy-associated genes is increased at 6 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
dilated cardiomyopathy | DOID:12930 |
OMIM:PS115200 |
J:134581 |