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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Rab1a)medGwd
transgene insertion medium, Gerald W Dorn II
MGI:5904947
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Rab1a)medGwd/0 involves: FVB/N MGI:5904950


Genotype
MGI:5904950
tg1
Allelic
Composition
Tg(Myh6-Rab1a)medGwd/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Golgi stack and surrounding transitional vesicles are enlarged and increased in number in 8 week old left ventricular cardiomyocytes
• degenerative myelin figures are seen in both ventricular and atrial cardiomyocytes at 8 weeks of age
• atrial myocytes contain overabundant atrial natriuretic peptide granules
• cardiomyocyte volume is increased by 100% and 13% in cells from left and right ventricles, respectively
• myocyte size, measured as cell capacitance, is increased indicating hypertrophy
• cardiac mass is increased already at 6 weeks of age and myocyte size is increased
• expression of hypertrophy-associated genes is increased at 6 weeks of age
• mice show progressive development of dilated cardiomyopathy after 12-24 weeks of age
• ventricular myocyte contractile function, measured as either the extent or maximal rate of unloaded shortening is depressed
• echocardiographic left ventricular fractional shortening progressively deteriorates overtime after 12-24 weeks of age
• L-type calcium channel current is depressed in myocytes
• amplitude of calcium transient is normal in ventricular myocytes, but calcium uptake is depressed

muscle
• Golgi stack and surrounding transitional vesicles are enlarged and increased in number in 8 week old left ventricular cardiomyocytes
• degenerative myelin figures are seen in both ventricular and atrial cardiomyocytes at 8 weeks of age
• atrial myocytes contain overabundant atrial natriuretic peptide granules
• cardiomyocyte volume is increased by 100% and 13% in cells from left and right ventricles, respectively
• myocyte size, measured as cell capacitance, is increased indicating hypertrophy
• mice show progressive development of dilated cardiomyopathy after 12-24 weeks of age
• ventricular myocyte contractile function, measured as either the extent or maximal rate of unloaded shortening is depressed
• echocardiographic left ventricular fractional shortening progressively deteriorates overtime after 12-24 weeks of age

growth/size/body
• cardiac mass is increased already at 6 weeks of age and myocyte size is increased
• expression of hypertrophy-associated genes is increased at 6 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
dilated cardiomyopathy DOID:12930 OMIM:PS115200
J:134581





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory